The role of platelets, neutrophils and endothelium in COVID-19 infection

E Falcinelli, E Petito, P Gresele - Expert Review of Hematology, 2022 - Taylor & Francis
Introduction COVID-19 is associated to an increased risk of thrombosis, as a result of a
complex process that involves the activation of vascular and circulating cells, the release of …

Hemostasis without clot formation–how platelets guard the vasculature in inflammation, infection, and malignancy

R Kaiser, R Escaig, L Nicolai - Blood, 2023 - Elsevier
Platelets are key vascular effectors in hemostasis, with activation signals leading to fast
recruitment, aggregation, and clot formation. The canonical process of hemostasis is well …

Catechol-chitosan/carboxymethylated cotton-based Janus hemostatic patch for rapid hemostasis in coagulopathy

Q Xu, E Hu, H Qiu, L Liu, Q Li, B Lu, K Yu, F Lu… - Carbohydrate …, 2023 - Elsevier
Uncontrolled bleeding is the leading cause of death, and the death risk of bleeding from
coagulopathy is even higher. By infusing the relevant coagulation factors, bleeding in …

Platelet-mimicking nanosponges for functional reversal of antiplatelet agents

J Xu, N Yan, C Wang, C Gao, X Han, C Yang… - Circulation …, 2023 - Am Heart Assoc
Background: During long-term antiplatelet agents (APAs) administration, patients with
thrombotic diseases take a fairly high risk of life-threatening bleeding, especially when in …

Rapid hemostatic antibacterial self-gelling powder based on methacryloylsulfonyl betaine and quaternized carboxymethyl chitosan

J Deng, Z Wang, J Xing - Journal of the Mechanical Behavior of Biomedical …, 2023 - Elsevier
Hemostatic powders can be used for deep wounds and wounds with irregular shapes that
are frequently inaccessible to traditional hemostatic dressings like hemostatic gauze …

State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding

C Feng, L Yang - International Wound Journal, 2024 - Wiley Online Library
Traumatic haemorrhage is a prevalent clinical condition, and effective and timely
haemostasis is crucial for the preservation of patients' lives. In recent years, injectable …

Preparation of porous carbon spheres by templated self-assembly for rapid hemostasis

Y Shi, S Ding, T Liu, K Hou, S Liu, F Li - Microporous and Mesoporous …, 2024 - Elsevier
Porous carbon spheres (PCS) with different specific surface areas and porous structures
were prepared by templated self-assembly method. The as-prepared PCS had uniform …

[HTML][HTML] Treatment of inherited platelet disorders: current status and future options

C Bargehr, R Knöfler, W Streif - Hämostaseologie, 2023 - thieme-connect.com
Inherited platelet disorders (IPDs) comprise a heterogeneous group of entities that manifest
with variable bleeding tendencies. For successful treatment, the underlying platelet disorder …

Engineered Intravenous Therapies For Trauma

TJ Pichon, NJ White, SH Pun - Current Opinion in Biomedical Engineering, 2023 - Elsevier
Trauma leading to severe hemorrhage and shock on average kills patients within 3 to 6
hours after injury. With average prehospital transport times reaching 1-6 hours in low-to …

Thrombotic microenvironment responsive crosslinking cyclodextrin metal-organic framework nanocarriers for precise targeting and thrombolysis

C Yuan, Y Ye, E Hu, R Xie, B Lu, K Yu, W Ding… - Carbohydrate …, 2024 - Elsevier
Global public health is seriously threatened by thrombotic disorders because of their high
rates of mortality and disability. Most thrombolytic agents, especially protein-based …