This article provides a brief overview of the history of substance P from its discovery in the
1930s to the present day. The development of substance P receptor agonists and …

Figure 1. Schematic diagram of the major components of chronic inflammatory and
neuropathic pain.(a) Persistent inflammatory pain models. The most important component of …

Background Tibia fracture followed by cast immobilization in rats evokes nociceptive,
vascular, epidermal, and bone changes resembling complex regional pain syndrome …

Purpose: The purpose of this study was to test the role of substance P (SP) and its receptor
neurokinin 1 (NK1R) on ocular surface pain. Methods: Eight-week-old C57BL6/N (wild type …

Anti-epileptic drugs (AEDs) are increasingly used for the treatment of neuropathic pain.
Oxcarbazepine is a recently introduced AED that is effective in treating epilepsy and has an …

Peripheral nerve injury in humans can produce a persistent pain state characterized by
spontaneous pain and painful responses to normally innocuous stimuli (allodynia). Here we …

Purpose To test long-term ocular toxicity and analgesic/anti-inflammatory efficacy of two
novel ocular formulations of neurokinin 1 receptor (NK1R) antagonist Aprepitant. Methods …

Although many studies have demonstrated a role for substance P in pain, there have been
conflicting reports implicating the involvement of substance P in neuropathic pain models. In …

Sciatic nerve section in rats evokes chronic hindlimb edema, pain behavior, and
hyperalgesia, a syndrome resembling complex regional pain syndrome (CRPS II) in man …

Various hypotheses have been proposed to account for the mechanical hyperalgesia and
spontaneous pain seen in animal models of peripheral neuropathy. The purpose of the …