Background Treatment of cancer is increasingly more effective but is associated with short
and long term side effects. Oral side effects remain a major source of illness despite the use …

The term mucositis is coined to describe the adverse effects of radiation and chemotherapy
treatments. Mucositis is one of the most common adverse reactions encountered in radiation …

Purpose Intestinal mucositis and diarrhea are common manifestations of anticancer
regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs. These side …

Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is
characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it …

The gastrointestinal tract is particularly vulnerable to off-target effects of antineoplastic drugs
because intestinal epithelial cells proliferate rapidly and have a complex immunological …

Cyclophosphamide (CTX), a common anticancer drug, can cause a variety of side effects
such as immunosuppression and intestinal mucosal injury. Polysaccharides are the major …

Keratinocyte growth factor (KGF) is a paracrine-acting, epithelial mitogen produced by cells
of mesenchymal origin. It is a member of the fibroblast growth factor (FGF) family, and acts …

Abstract The chemotherapeutic agent 5‐fluorouracil (5‐FU) causes intestinal mucositis with
severe diarrhoea, but the pathogenesis is not fully understood. In this study, we investigated …

Intestinal inflammation represented by inflammatory bowel disease (IBD) has become a
global epidemic disease and the number of patients with IBD continues to increase. This …

Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent. However, its
use is associated with several debilitating adverse effects such as intestinal mucositis (IM) …