Clinical relevance of KRAS in human cancers
S Jančík, J Drábek, D Radzioch… - BioMed Research …, 2010 - Wiley Online Library
The KRAS gene (Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …
encodes a small GTPase transductor protein called KRAS. KRAS is involved in the …
Molecular subtyping of small cell lung cancer
J Liang, X Guan, G Bao, Y Yao, X Zhong - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC), originating from lung neuroendocrine stem cells, is a
common pulmonary malignant tumor. SCLC, with poor prognoses, accounts for …
common pulmonary malignant tumor. SCLC, with poor prognoses, accounts for …
Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4–ALK Fusion Gene
T Takahashi, M Sonobe, M Kobayashi… - Annals of surgical …, 2010 - Springer
Background A fusion gene between echinoderm microtubule-associated protein-like 4
(EML4) and the anaplastic lymphoma kinase (ALK) has recently been identified in non-small …
(EML4) and the anaplastic lymphoma kinase (ALK) has recently been identified in non-small …
Tyrphostins and other tyrosine kinase inhibitors
A Levitzki, E Mishani - Annu. Rev. Biochem., 2006 - annualreviews.org
The development of tyrosine phosphorylation inhibitors has transformed the approach to
cancer therapy and is likely to affect other fields of medicine. In spite of the conservation …
cancer therapy and is likely to affect other fields of medicine. In spite of the conservation …
Differential Constitutive Activation of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer Cells Bearing EGFR Gene Mutation and Amplification
T Okabe, I Okamoto, K Tamura, M Terashima… - Cancer research, 2007 - AACR
The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth
factor receptor (EGFR) in patients with non–small cell lung cancer (NSCLC) and the …
factor receptor (EGFR) in patients with non–small cell lung cancer (NSCLC) and the …
Progress towards personalized medicine
S Bates - Drug discovery today, 2010 - Elsevier
Personalized medicine is the tailoring of therapies to defined subsets of patients based on
their likelihood to respond to therapy or their risk of adverse events. The advent of improved …
their likelihood to respond to therapy or their risk of adverse events. The advent of improved …
Anticancer potential of thiazole derivatives: a retrospective review
S Jain, S Pattnaik, K Pathak, S Kumar… - Mini reviews in …, 2018 - ingentaconnect.com
This review brings forth the potential of thiazole derivatives for their anticancer activities. The
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
emphasis is placed on the structural diversity of thiazole derivatives, responsible for their …
[图书][B] The biological basis of cancer
RG McKinnell - 1998 - books.google.com
This text is designed to be used for an undergraduate course on cancer. It covers everything
from the molecular to the clinical aspects of the subject, and has a lengthy bibliography …
from the molecular to the clinical aspects of the subject, and has a lengthy bibliography …
Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido [2, 1-b] benzothiazole derivatives
MT Gabr, NS El-Gohary, ER El-Bendary… - European journal of …, 2014 - Elsevier
New series of benzothiazole and pyrimido [2, 1-b] benzothiazole derivatives were
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …