Adeno-associated virus (AAV) vectors were shown capable of high efficiency transduction of
both dividing and nondividing cells and tissues. AAV-mediated transduction leads to stable …

Gene therapy holds promise for the treatment of cardiovascular diseases for which effective
pharmacological therapies are insufficient or unavailable. Recent studies have suggested …

Thyrotropin-releasing hormone (TRH) plays an important role in central cardiovascular
regulation. Recently, we described that the TRH precursor gene overexpression induces …

Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a
number of peptides exerting several roles as a hormone and as a neuropeptide. Its …

Background: Salt-induced hypertension is mediated via the α2B-adrenergic receptor (AR)
subtype. In α2B-AR gene knockout mice, blood pressure (BP) does not rise with salt loading …

Related US Application Data (60) Provisional application No. 60/494,184, filed on Aug. 11,
2003, provisional application No. 60/494,185, filed on Aug. 11, 2003, provisional application …

Heart disease remains the leading cause of death and morbidity in the western world
despite significant advances in cardiovascular (CVS) therapeutics. Since the 1960s clinical …

In this short review, we present a historical perspective of the treatment of hypertension,
highlight some current issues and look to the possible future of antihypertensive therapy …

The sympathetic nervous system (SNS) elicits its effects by controlling the release of
catecholamines, whose actions are mediated by their binding to adrenergic receptors (AR) …

The invention relates to methods and compositions for selec tively directing stem cells to a
target tissue within a subject using a system that employs one or more vectors that contain a …