Lamiophlomis rotata (L. rotata, Duyiwei) is an orally available Tibetan analgesic herb widely
prescribed in China. Shanzhiside methylester (SM) is a principle effective iridoid glycoside …

Apart from reducing the acid secretion, omeprazole inhibits activation of the nuclear factor-
κB, release of inflammatory cytokines and chemotaxis of neutrophils. These mechanisms …

Background: The participation of spinal P2X receptors in neuropathic pain is well
recognized. However, the role of P2Y receptors has been less studied. The purpose of this …

Abstract Treatment of neuropathic pain remains challenging as the etiology is
heterogeneous and pathomechanisms are incompletely understood. One possible …

Abstract Alzheimer's disease (AD), as an advanced neurodegenerative disease, is
characterized by the everlasting impairment of memory, which is determined by …

Background and aims Painful diabetic neuropathy significantly affects the quality of life in
people with diabetic peripheral neuropathy (DPN). Existing pharmacological agents have …

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available
analgesics, and novel mechanism-based therapies are being evaluated for this debilitating …

Abstract Background and Objective Neuropathic pain arises as a direct consequence of a
lesion or disease affecting the somatosensory system. A number of preclinical studies have …

Damage on one side of the body can also result in pain on the contralateral unaffected side,
called mirror-image pain (MIP). Currently, the mechanisms responsible for the development …

Objective To evaluate whether intraganglionic calcitonin gene-related peptide induced
differential migraine-like responses in male and female rats. Methods Calcitonin gene …