Napabucasin (BBI608) is an orally administered small molecule that blocks stem cell activity
in cancer cells by targeting the signal transducer and activator of transcription 3 pathway …

In recent years, the increasing awareness that somatic mutations and other genetic
aberrations drive human malignancies has led us within reach of personalized cancer …

BACKGROUND Although the presence of genetic heterogeneity within the tumors of
individual patients is established, it is unclear whether greater heterogeneity predicts a …

Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma
skin cancer (NMSC) development, especially in association with UVB. Extensively studied …

Purpose: Durable complete remission of metastatic renal cell carcinoma (RCC) has rarely
been achieved with current treatment modalities. To solve this problem, alternative …

Purpose Colorectal cancer (CRC) is markedly heterogeneous and develops progressively
toward malignancy through several stages which include stroma (ST), benign hyperplasia …

Background: Since PI3K/AKT/mTOR pathway activation diminishes the effects of hormone
therapy, combining aromatase inhibitors (anatrozole) with mTOR inhibitors (everolimus) was …

OBJECTIVE. The purpose of this study was to quantitatively evaluate the role of intratumoral
heterogeneity of 18F-FDG uptake in characterizing nasopharyngeal carcinoma (NPC) …

Oral Diseases (2012) 18, 469–476 Background: Multistep pathways and mechanisms are
involved in the development of oral cancer. Chromosomal alterations are one of such key …

Despite the advances in diagnosis and treatment of oral squamous cell carcinoma (OSCC),
mortality and morbidity rates have not improved over the past decade. A major drawback in …