Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Mitochondrial miRNAs (MitomiRs): their potential roles in breast and other cancers

E Erturk, OE Onur, O Akgun, G Tuna, Y Yildiz, F Ari - Mitochondrion, 2022 - Elsevier
Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are
non-coding RNAs that are involved in the post-transcriptional regulation of gene expression …

Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer

W Shi, T Wartmann, S Accuffi, S Al-Madhi… - British Journal of …, 2024 - nature.com
Introduction Pancreatic cancer is a highly aggressive cancer, and early diagnosis
significantly improves patient prognosis due to the early implementation of curative-intent …

The chromatin-associated RNAs in gene regulation and cancer

J Tang, X Wang, D Xiao, S Liu, Y Tao - Molecular Cancer, 2023 - Springer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into
proteins or execute gene regulatory functions. Many RNAs associate with chromatin directly …

High electrochemical active Au-NP/2D zinc-metal organic frameworks heterostructure-based ECL sensor for the miRNA-522 detection in triple negative breast cancer

W Zhong, Y Zhang, H Zhao, Z Liang, J Shi, Q Ma - Talanta, 2023 - Elsevier
In this work, a novel electrochemiluminescence (ECL) sensor has been developed to detect
the miRNA-522 in the tumor tissues of triple-negative breast cancer (TNBC) patients. Au …

Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers

M Zhou, X He, C Mei, C Ou - Biomarker Research, 2023 - Springer
Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune cell
types in the tumor microenvironment (TME), account for approximately 50% of the local …

DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression

K Xu, S Sun, M Yan, J Cui, Y Yang, W Li… - Frontiers in …, 2022 - frontiersin.org
DEAD-box (DDX) 5 and DDX17, which belong to the DEAD-box RNA helicase family, are
nuclear and cytoplasmic shuttle proteins. These proteins are expressed in most tissues and …

[HTML][HTML] Ugonin P inhibits lung cancer motility by suppressing DPP-4 expression via promoting the synthesis of miR-130b-5p

CY Wu, SS Ghule, CC Liaw, D Achudhan… - Biomedicine & …, 2023 - Elsevier
Lung cancer is the leading cause of cancer-related death worldwide, and the survival rate of
metastatic lung cancer is exceedingly low. Helminthostatchys Zeylanica (H. Zeylanica) is a …

[HTML][HTML] Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions

RKME Alsayed, KSAM Sheikhan, MA Alam… - Seminars in Cancer …, 2023 - Elsevier
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to
indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a …