GABAA receptors as molecular targets of general anesthetics: identification of binding sites
provides clues to allosteric modulation - PMC Back to Top Skip to main content NIH NLM Logo …

Thymol is a naturally occurring phenolic monoterpene known for its anti-microbial and anti-
oxidant properties. It is used in dental practice and in anaesthetic halothane preparations …

Abstract GABA A receptors (GABA A Rs) mediate rapid inhibitory transmission in the brain.
GABA A Rs are ligand-gated chloride ion channel proteins and exist in about a dozen or …

The nicotinic acetylcholine receptor is a well characterized ligandgated ion channel, yet a
proper description of the mechanisms involved in gating, opening, closing, ligand binding …

GABAA receptors are ligand‐gated chloride channels composed of five subunits that can
belong to different subunit classes. The existence of 19 different subunits gives rise to a …

The γ-aminobutyric acid type A receptor (GABAAR) is a target for general anesthetics of
diverse chemical structures, which act as positive allosteric modulators at clinical doses …

Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for
stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be …

Propofol is the most commonly used general anesthetic in humans. Our understanding of its
mechanism of action has focused on its capacity to potentiate inhibitory systems in the brain …

This paper provides new insights of how general anaesthetic research should be carried out
in the future by an analysis of what we know, what we do not know and what we would like …

The Cys-loop ligand-gated ion channel superfamily is a major group of neurotransmitter–
activated receptors in the central and peripheral nervous system. The superfamily includes …