Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine …
RB Parikh, M Bali, MH Akabas - Journal of Biological Chemistry, 2011 - ASBMB
GLIC is a homopentameric proton-gated, prokaryotic homologue of the Cys loop receptor
family of neurotransmitter-gated ion channels. Recently, crystal structures of GLIC …
family of neurotransmitter-gated ion channels. Recently, crystal structures of GLIC …
Alphaxalone Binds in Inner Transmembrane β+–α− Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors
AM Ziemba, A Szabo, DW Pierce, M Haburcak… - …, 2018 - pubs.asahq.org
Background Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants,
amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric …
amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric …
Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster
OH Zalucki, H Menon, B Kottler, R Faville, R Day… - …, 2015 - pubs.asahq.org
Background: Recent evidence suggests that general anesthetics activate endogenous sleep
pathways, yet this mechanism cannot explain the entirety of general anesthesia. General …
pathways, yet this mechanism cannot explain the entirety of general anesthesia. General …
Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid …
NP Franks - Anesthesiology, 2015 - pubs.asahq.org
Background: Most anesthetics, particularly intravenous agents such as propofol and
etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the …
etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the …
The impact of genetic factors on response to anaesthetics
A Mikstacki, M Skrzypczak-Zielinska… - Advances in medical …, 2013 - Elsevier
In recent years, exceptional progress has been observed in pharmacogenetics, ie
investigations of inherited conditioning of the organism's response to drugs or xenobiotics …
investigations of inherited conditioning of the organism's response to drugs or xenobiotics …
GABAergic pharmacological activity of propofol related compounds as possible enhancers of general anesthetics and interaction with membranes
GN Reiner, L Delgado-Marín, N Olguín… - Cell biochemistry and …, 2013 - Springer
Phenol compounds, such as propofol and thymol, have been shown to act on the GABA A
receptor through interaction with specific sites of this receptor. In addition, considering the …
receptor through interaction with specific sites of this receptor. In addition, considering the …
A single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol
G Moraga-Cid, GE Yevenes, G Schmalzing… - The Journal of the …, 2011 - pubs.asahq.org
Background The intravenous anesthetic propofol acts as a positive allosteric modulator of
glycine (GlyRs) and γ-aminobutyric acid type A (GABAARs) receptors. Although the role of …
glycine (GlyRs) and γ-aminobutyric acid type A (GABAARs) receptors. Although the role of …
Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics
DS Stewart, DW Pierce, M Hotta, AT Stern, SA Forman - PloS one, 2014 - journals.plos.org
Etomidate and propofol are potent general anesthetics that act via GABAA receptor allosteric
co-agonist sites located at transmembrane β+/α− inter-subunit interfaces. Early experiments …
co-agonist sites located at transmembrane β+/α− inter-subunit interfaces. Early experiments …
Interplay of phenol and isopropyl isomerism in propofol from broadband chirped-pulse microwave spectroscopy
The conformational equilibrium of the general anesthetic propofol (2, 6-diisopropylphenol)
has been studied in a supersonic expansion using broadband chirped-pulse microwave …
has been studied in a supersonic expansion using broadband chirped-pulse microwave …
GABA_A 受体部分介导丙泊酚在中脑导水管周围灰质腹外侧区的致痛觉过敏作用
王擒云， 杨建平， 戴体俊， 张慧娟 - 中国药理学通报, 2006 - cqvip.com
目的观察丙泊酚在vlPAG 对大鼠伤害性感受的影响及GABAA 受体在其中可能的作用.
方法Sprague-Dawley (SD)♀ 大鼠随机分组, 丙泊酚(Propofol, Pro) 和荷包牡丹碱(Bicuculline …
方法Sprague-Dawley (SD)♀ 大鼠随机分组, 丙泊酚(Propofol, Pro) 和荷包牡丹碱(Bicuculline …