Propofol is an intravenous general anesthetic that alters neuronal excitability by modulating
agonist responses of pentameric ligand-gated ion channels (pLGICs). Evidence suggests …

Objective This study was implemented to evaluate the effect of genistein and propofol on
intracranial tumour model. Methods Male Fischer 344 rats were subjected to intracranial …

We synthesized the R-and S-enantiomers of ethyl 1-(1-(4-(3-((trifluoromethyl)-3 H-diazirin-3-
yl) phenyl) ethyl)-1 H-imidazole-5-carboxylate (trifluoromethyldiazirinyl-etomidate), or TFD …

γ-Aminobutyric acid type-A receptors (GABAARs) play a critical role in neural transmission
by mediating the inhibitory neural firing and are the target of many psychiatric drugs. Among …

Propofol is an intravenous anesthetic that is widely used for anesthesia and sedation.
Dendritic cells (DC) are one of the crucial immune cells that bridge innate and adaptive …

γ-Aminobutyric acid (GABA) binding to GABA A receptors (GABA A Rs) triggers
conformational movements in the α 1 and β 2 pre-M1 regions that are associated with …

In the present study, behavioral and in vivo electrophysiological methods were used to
examine the peripheral effects of propofol on tonic ongoing pain-related responses …

Multiple approaches, including cryogenic electron microscopy (cryo-EM), indicate that the
anesthetics etomidate and propofol modulate α 1 β 2/3 γ 2 GABAA receptors by binding in …

This study examined whether propofol altered [Ca2+] i and caused cell death in DBTRG-
05MG cells. Propofol at 400–1000μM increased [Ca2+] i in a concentration-dependent …

GABA A receptors mediate fast inhibitory synaptic transmission. The transmembrane ion
channel is lined by a ring of five α helices, M2 segments, one from each subunit. An outer …