In this review we sum‐up the knowledge about bZIP G‐box binding factors (GBFs), which
possess an N‐terminal, proline‐rich domain. The GBF has been one of the most extensively …

The abundant cytoskeletal protein actin has numerous cytoplasmic roles. Although there are
many reports of the presence of actin in the nucleus, in general they have been discounted …

The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to
the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is …

STAT1 functions as both a constitutive transcriptional regulator and, in response to cytokine
stimulation of cells, as an inducible tyrosine‐phosphorylated transcription factor. Here, we …

We previously designed and synthesized an NF-κB inhibitor,
dehydroxymethylepoxyquinomicin (DHMEQ), that showed anti-inflammatory activity in vivo …

Max is a common dimerization partner for a family of transcription factors (Myc, Mad [or Mxi]),
and Mnt [or Rox] proteins) that regulate cell growth, proliferation, and apoptosis. We recently …

ATF2 and c‐Jun are key components of activating protein‐1 and function as homodimers or
heterodimers. c‐Jun–ATF2 heterodimers activate the expression of many target genes …

Transport of macromolecules between the nucleus and the cytoplasm is an essential
necessity in eukaryotic cells, since the nuclear envelope separates transcription from …

During an acute, systemic inflammation, the liver is triggered by blood-borne pro-
inflammatory cytokines such as Tumor Necrosis Factor α, Interleukin-1 β and Interleukin-6 …

Signals received at distal synapses of neurons must be conveyed to the nucleus to initiate
the changes in transcription that underlie long-lasting synaptic plasticity. The presence of …