Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis
Background Anakinra might improve the prognosis of patients with moderate to severe
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ …
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ …
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
An open label trial of anakinra to prevent respiratory failure in COVID-19
E Kyriazopoulou, P Panagopoulos, S Metallidis… - Elife, 2021 - elifesciences.org
Background: It was studied if early suPAR-guided anakinra treatment can prevent severe
respiratory failure (SRF) of COVID-19. Methods: A total of 130 patients with suPAR≥ 6 ng/ml …
respiratory failure (SRF) of COVID-19. Methods: A total of 130 patients with suPAR≥ 6 ng/ml …
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
JD Crapser, MA Arreola, KI Tsourmas… - Cellular & molecular …, 2021 - nature.com
Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
[HTML][HTML] Systematic review of safety and efficacy of IL-1-targeted biologics in treating immune-mediated disorders
DD Arnold, A Yalamanoglu, O Boyman - Frontiers in Immunology, 2022 - frontiersin.org
Background The cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …
disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be …
Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation
YY Chao, A Puhach, D Frieser, M Arunkumar… - Nature …, 2023 - nature.com
It has been shown that innate immune responses can adopt adaptive properties such as
memory. Whether T cells utilize innate immune signaling pathways to diversify their …
memory. Whether T cells utilize innate immune signaling pathways to diversify their …
COVID-19 infection: an overview on cytokine storm and related interventions
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …
syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This …
Post-COVID-19 patients who develop lung fibrotic-like changes have lower circulating levels of IFN-β but higher levels of IL-1α and TGF-β
C Colarusso, A Maglio, M Terlizzi, C Vitale, A Molino… - Biomedicines, 2021 - mdpi.com
Purpose: SARS-CoV-2 infection induces in some patients a condition called long-COVID-19,
herein post-COVID-19 (PC), which persists for longer than the negative oral-pharyngeal …
herein post-COVID-19 (PC), which persists for longer than the negative oral-pharyngeal …
Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management
ABSTRACT Introduction SARS-CoV-2, the causative agent of COVID-19, attacks the
immune system causing an exaggerated and uncontrolled release of pro-inflammatory …
immune system causing an exaggerated and uncontrolled release of pro-inflammatory …
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …