Triple-negative breast cancer (TNBC) is the most aggressive and hard-to-treat form of breast
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …

MYC is a proto-oncogene that encodes a powerful regulator of transcription and cellular
programs essential for normal development, as well as the growth and survival of various …

Undermining transcriptional addiction, the dependence of cancers on selected
transcriptional programs, is critically important for addressing cancers with high unmet …

Cyclin-dependent kinase 9 (CDK9) is a member of the transcription CDK subfamily. In this
work, we preliminarily demonstrated the feasibility of CDK9 as a potent target of treatment for …

Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the
world. Histone‐lysine N‐methyltransferase EHMT2 (also known as G9a) is a histone …

Myeloid cell leukemia 1 (Mcl-1) is a key regulator of the intrinsic apoptosis pathway.
Overexpression of Mcl-1 is correlated with high tumor grade, poor survival, and both intrinsic …

The combination of endocrine therapy and CDK4/6 inhibitors such as palbociclib is an
effective and well-tolerated treatment for estrogen receptor–positive (ER+) breast cancer, yet …

To evade cell cycle controls, malignant cells rely upon rapid expression of select proteins to
mitigate proapoptotic signals resulting from damage caused by both cancer treatments and …

Adult T-cell leukemia/lymphoma (ATL) is a hematopoietic malignancy with a poor prognosis
that develops in approximately 5% of human T-cell leukemia virus type 1 (HTLV-1) carriers …

Background: Colon cancer is a malignant tumor with high malignancy and a low survival
rate whose heterogeneity limits systemic immunotherapy. Transforming growth factor-β (TGF …