Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …
oxidant molecules with vastly different properties and biological functions that range from …
Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy
HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
Understanding mechanisms of antioxidant action in health and disease
B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …
the development of certain human diseases whilst also performing physiological functions …
Oxidative stress: Concept and some practical aspects
H Sies - Antioxidants, 2020 - mdpi.com
Oxidative stress is defined as “an imbalance between oxidants and antioxidants in favor of
the oxidants, leading to a disruption of redox signaling and control and/or molecular …
the oxidants, leading to a disruption of redox signaling and control and/or molecular …
[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
B Wang, Y Wang, J Zhang, C Hu, J Jiang, Y Li… - Archives of …, 2023 - Springer
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …
and other related products, which play an important role in the process of cell death …
Redox homeostasis maintained by GPX4 facilitates STING activation
M Jia, D Qin, C Zhao, L Chai, Z Yu, W Wang… - Nature …, 2020 - nature.com
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate
immune responses against microbial infection and tumors. Redox homeostasis is the …
immune responses against microbial infection and tumors. Redox homeostasis is the …
[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis
H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …
[HTML][HTML] Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress
H Sies - Redox biology, 2017 - Elsevier
Hydrogen peroxide emerged as major redox metabolite operative in redox sensing,
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …
signaling and redox regulation. Generation, transport and capture of H 2 O 2 in biological …