Despite the development of novel targeted drugs, the molecular heterogeneity of diffuse
large B-cell lymphoma (DLBCL) still poses a substantial therapeutic challenge. DLBCL can …

Cutaneous T cell lymphomas (CTCL) comprise of a heterogeneous group of non-Hodgkin
lymphomas derived from skin-homing T cells. Variation in clinical presentation and lack of …

Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐
homing mature T‐cells causing severe symptoms and high mortality through chronic …

Targeted therapies for cutaneous T-cell lymphoma (CTCL) are limited and curative
approaches are lacking. Furthermore, relapses and drug induced side effects are major …

Reactive oxygen species (ROS) are central to inter-and intracellular signaling. Their
localized and transient effects are due to their short half-life, especially when generated in …

This study focused on soluble (s) CD25-mediated regulation of IL-2 signaling in murine and
human CD4+ T cells. Recombinant sCD25 reversibly sequestered IL-2 to limit acute …

Simple Summary The combination of Resminostat (HDACi) and Ruxolitinib (JAKi) exerted
cytotoxic effects and inhibited proliferation of CTCL cell lines (MyLa, SeAx) in vitro. The aim …

Background: Inhibiting proliferation and inducing apoptosis of myofibroblasts is becoming
one of the promising and effective ways to treat hypertrophic scar. ABT-263, as an orally …

Non-small cell lung cancer (NSCLC) patients with epithermal growth factor receptor (EGFR)
mutations can be treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs), however …

Insulinoma is an excessive insulin-released beta cell tumor. Pancreas cancer is one of the
deadliest malignant neoplasms. Exosomes are secreted cell membrane vesicles containing …