Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions

K Wang, Q Gao, T Zhang, J Rao, L Ding… - Drug metabolism …, 2020 - Taylor & Francis
Due to the rapidly increasing global interest in the use of herbs, phytomedicines and other
natural products as medical or complementary remedies, concerns about the clinical …

Research progress in the pharmacological activities, toxicities, and pharmacokinetics of sophoridine and its derivatives

Q Tang, Y Liu, X Peng, B Wang, F Luan… - Drug Design …, 2023 - Taylor & Francis
Sophoridine is a natural quinolizidine alkaloid and a bioactive ingredient that can be
isolated and identified from certain herbs, including Sophora flavescens Alt, Sophora …

Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue …

Q Wu, Z Duan, L Huang, Z Li - Pharmaceutical Biology, 2022 - Taylor & Francis
Context Kuhuang (KH) injection is a widely used anticholestatic drug in the clinic and the
mechanisms are still unclear. Objective This study uses a new 3D tissue-engineered (TE) …

A simple, rapid and green method based on pulsed potentiostatic electrodeposition of reduced graphene oxide on glass carbon electrode for sensitive voltammetric …

F Wang, Y Wu, K Lu, L Gao, B Ye - Electrochimica Acta, 2014 - Elsevier
A simple, rapid and green method was described for sensitive voltammetric detection of
sophoridine based on graphene nanosheets directly deposited onto a glassy carbon …

Electrochemical behavior of sophoridine at a new amperometric sensor based on l-Theanine modified electrode and its sensitive determination

Y Li, L Zou, G Song, K Li, B Ye - Journal of Electroanalytical Chemistry, 2013 - Elsevier
The electro-polymerization of l-Theanine was investigated for the first time on glassy carbon
electrode and the polymeric conditions and mechanism were discussed in detail. Hereafter …

Development of a highly sensitive electrochemiluminescence sophoridine sensor using Ru (bpy) 32+ integrated carbon quantum dots–polyvinyl alcohol composite …

Z Liu, X Zhang, L Cui, K Wang, H Zhan - Sensors and Actuators B …, 2017 - Elsevier
A facile electrochemiluminescence (ECL) sensing platform for the sensitive analysis of
sophoridine was constructed using Ru (bpy) 3 2+/carbon quantum dots–polyvinyl alcohol …

Physiologically based pharmacokinetics of matrine in the rat after oral administration of pure chemical and ACAPHA

G Gao, FCP Law - Drug metabolism and disposition, 2009 - ASPET
ACAPHA, a botanical drug for the treatment of human esophageal cancer in China, is under
investigation as a lung cancer chemoprevention agent at the BC Cancer Agency …

液相色谱-串联质谱法与气相色谱-串联质谱法测定茶叶中苦参碱残留量

陈红平, 刘新, 汪庆华, 蒋迎, 王川丕 - 分析测试学报, 2023 - fxcsxb.com
建立了茶叶中苦参碱残留检测的两种前处理方法, 比较了液相色谱-串联质谱(LC-MS/MS)
与气相色谱-串联质谱(GC-MS/MS) 检测茶叶中苦参碱残留量分析方法的适用性. 结果表明 …

Simultaneously determination of five ginsenosides in rabbit plasma using solid-phase extraction and HPLC/MS technique after intravenous administration of ' …

K Yu, Y Ma, Q Shao, H Qu, Y Cheng - Journal of pharmaceutical and …, 2007 - Elsevier
In this study, a sensitive and reliable analytical method for the simultaneous determination of
five ginsenosides (Rg1, Rf, Re, Rd and Rb1) in rabbit plasma was developed by high …

Matrine determination and pharmacokinetics in human plasma using LC/MS/MS

XL Zhang, HR Xu, WL Chen, NN Chu, XN Li… - … of Chromatography B, 2009 - Elsevier
A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for
the determination of matrine in human plasma extracted by isopropanol: ethyl acetate (v/v, 5 …