Sunlight and Vitamin D: A global perspective for health

M Wacker, MF Holick - Dermato-endocrinology, 2013 - Taylor & Francis
Vitamin D is the sunshine vitamin that has been produced on this earth for more than 500
million years. During exposure to sunlight 7-dehydrocholesterol in the skin absorbs UV B …

Cathelicidins: immunomodulatory antimicrobials

RM Van Harten, E Van Woudenbergh, A Van Dijk… - Vaccines, 2018 - mdpi.com
Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions.
These effector molecules of the innate immune system of many vertebrates are diverse in …

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

Y Lai, RL Gallo - Trends in immunology, 2009 - cell.com
Antimicrobial peptides (AMPs) are widely expressed and rapidly induced at epithelial
surfaces to repel assault from diverse infectious agents including bacteria, viruses, fungi and …

[HTML][HTML] Antimicrobial peptides: old molecules with new ideas

T Nakatsuji, RL Gallo - Journal of investigative dermatology, 2012 - Elsevier
Almost 90 years have passed since Alexander Fleming discovered the antimicrobial activity
of lysozyme, the first natural antibiotic isolated from our body. Since then, various types of …

[HTML][HTML] LL-37, the only human member of the cathelicidin family of antimicrobial peptides

UHN Dürr, US Sudheendra, A Ramamoorthy - Biochimica et Biophysica …, 2006 - Elsevier
Antimicrobial peptides and their precursor molecules form a central part of human and
mammalian innate immunity. The underlying genes have been thoroughly investigated and …

Human antimicrobial peptides and proteins

G Wang - Pharmaceuticals, 2014 - mdpi.com
As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles

G Wang - Journal of Biological Chemistry, 2008 - ASBMB
As a key component of the innate immunity system, human cathelicidin LL-37 plays an
essential role in protecting humans against infectious diseases. To elucidate the structural …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Antimicrobial peptides in 2014

G Wang, B Mishra, K Lau, T Lushnikova, R Golla… - Pharmaceuticals, 2015 - mdpi.com
This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …

Kallikrein‐mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin

K Yamasaki, J Schauber, A Coda, H Lin… - The FASEB …, 2006 - Wiley Online Library
The presence of cathelicidin antimicrobial peptides provides an important mechanism for
prevention of infection against a wide variety of microbial pathogens. The activity of …