[HTML][HTML] SMARCA4: Current status and future perspectives in non-small-cell lung cancer
Y Tian, L Xu, X Li, H Li, M Zhao - Cancer Letters, 2023 - Elsevier
SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung
SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …
Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress, and enhances the chemotherapeutic activity of widely used DNA damaging …
Although several ATR inhibitors are in development, there are unresolved questions
regarding their differential potency, molecular signatures of patients with cancer for …
regarding their differential potency, molecular signatures of patients with cancer for …
PBRM1 deficiency confers synthetic lethality to DNA repair inhibitors in cancer
RM Chabanon, D Morel, T Eychenne, L Colmet-Daage… - Cancer research, 2021 - AACR
Abstract Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …
[HTML][HTML] SMARCA4 and other SWItch/sucrose nonfermentable family genomic alterations in NSCLC: clinicopathologic characteristics and outcomes to immune …
Abstract Introduction The SWItch/Sucrose Nonfermentable (SWI/SNF) chromatin remodeling
complex acts as a regulatory component of transcription, and inactivating mutations (muts) …
complex acts as a regulatory component of transcription, and inactivating mutations (muts) …
The role of chromatin remodeler SMARCA4/BRG1 in brain cancers: a potential therapeutic target
SM Navickas, KA Giles, KH Brettingham-Moore… - Oncogene, 2023 - nature.com
The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …
in coordinating the molecular programs that underlie brain tumour development. BRG1 …
An extending ATR–CHK1 circuitry: the replication stress response and beyond
A Simoneau, L Zou - Current opinion in genetics & development, 2021 - Elsevier
The maintenance of genomic integrity relies on the coordination of a wide range of cellular
processes and efficient repair of DNA damage. Since its discovery over two decades ago …
processes and efficient repair of DNA damage. Since its discovery over two decades ago …
[HTML][HTML] A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung …
R Plummer, E Dean, HT Arkenau, C Redfern, AI Spira… - Lung Cancer, 2022 - Elsevier
Abstract Objectives Berzosertib (formerly M6620, VX-970) is an intravenous, highly potent
and selective, first-in-class ataxia telangiectasia and Rad3-related (ATR) protein kinase …
and selective, first-in-class ataxia telangiectasia and Rad3-related (ATR) protein kinase …
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer
X Zeng, B Yao, J Liu, GW Gong, M Liu, J Li… - NPJ Precision …, 2023 - nature.com
Genomic studies have demonstrated a high frequency of genetic alterations in components
of the SWI/SNF complex including the core subunit SMARCA4. However, the mechanisms of …
of the SWI/SNF complex including the core subunit SMARCA4. However, the mechanisms of …