Clinicopathological characteristics and treatment outcomes of advanced SMARCA4‐deficient thoracic tumors
A Wang, Y Jin, Z Cao, L Lu, Z Li - Cancer Medicine, 2024 - Wiley Online Library
Purpose SMARCA4‐deficient thoracic tumors, characterized by distinct clinicopathological,
morphological, immunohistochemical, and genetic features, differ significantly from …
morphological, immunohistochemical, and genetic features, differ significantly from …
Targeting SWI/SNF complexes in cancer: pharmacological approaches and implications
MR Dreier, J Walia, IL de la Serna - Epigenomes, 2024 - mdpi.com
SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
State of the biomarker science in ovarian cancer: a National Cancer Institute clinical trials planning meeting report
PURPOSE Despite therapeutic advances in the treatment of ovarian cancer (OC), 5-year
survival remains low, and patients eventually die from recurrent, chemotherapy-resistant …
survival remains low, and patients eventually die from recurrent, chemotherapy-resistant …
(mis)-Targeting of SWI/SNF complex (es) in cancer
The ATP-dependent chromatin remodeling complex SWI/SNF (also called BAF) is critical for
the regulation of gene expression. During the evolution from yeast to mammals, the BAF …
the regulation of gene expression. During the evolution from yeast to mammals, the BAF …
Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
BACKGROUND SMARCA4/BRG1‐deficient tumors and those that have loss of
SMARCA/BRG1 have been described as various aggressive carcinomas and sarcomas …
SMARCA/BRG1 have been described as various aggressive carcinomas and sarcomas …
Exploiting Cancer Synthetic Lethality in Cancer—Lessons Learnt from PARP Inhibitors
PARP inhibitors now have proven utility in the treatment of homologous recombination (HR)
defective cancers. These drugs, and the synthetic lethality effect they exploit, have not only …
defective cancers. These drugs, and the synthetic lethality effect they exploit, have not only …
[HTML][HTML] Esophageal carcinoma with SMARCA4 mutation: a narrative review for this rare entity
Methods The PubMed, Scopus, Ovid, and Google Scholar databases were extensively
reviewed. The references included in the articles were cross-examined to identify any …
reviewed. The references included in the articles were cross-examined to identify any …
The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy
M Sadek, A Sheth, G Zimmerman, E Hays… - Frontiers in Cell and …, 2022 - frontiersin.org
Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodelers hydrolyze ATP to push
and slide nucleosomes along the DNA thus modulating access to various genomic loci …
and slide nucleosomes along the DNA thus modulating access to various genomic loci …
Epigenetic Mediated Regulation of Cancer-Testis/Germline Antigen and Its Implication in Cancer Immunotherapy: A Treasure Map for Future Anticipatory Medicine
Implication and harnessing innovative therapy in targeting the molecular underpinning of
solid tumors are urgently needed. Previous seminal discoveries have elucidated …
solid tumors are urgently needed. Previous seminal discoveries have elucidated …
SNF5 promotes cell proliferation and immune evasion in non-small cell lung cancer
Y Chen, M Zhao, D Shen, Q Yi, L Tang - Bioengineered, 2022 - Taylor & Francis
Immune evasion is the process that tumor cells accelerate growth and metastasis by
evading the recognition and attack of immune cells. SNF5 is one of the core subunits of …
evading the recognition and attack of immune cells. SNF5 is one of the core subunits of …