Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

Emerging computational tools promise to revolutionize protein engineering for biocatalytic
applications and accelerate the development timelines previously needed to optimize an …

In this study, we generated a novel library approach for high throughput de novo
identification of humanized single-domain antibodies following camelid immunization. To …

Achieving cost-competitive bio-based processes requires development of stable and
selective biocatalysts. Their realization through in vitro enzyme characterization and …

Introduction: In this study, we demonstrate the feasibility of yeast surface display (YSD) and
nextgeneration sequencing (NGS) in combination with artificial intelligence and machine …

自然界中存在的酶拥有多种多样的功能, 它们已经被应用在工业生产和学术研究中,
但其中许多酶的性质和功能还不能完全满足应用需要, 通过改造来提升这类酶的某些特性是酶 …

Protein engineering has made significant contributions to industries such as agriculture,
food, and pharmaceuticals. In recent years, directed evolution combined with artificial …

Optimizing the metabolic pathways of microbial cell factories is essential for establishing
viable biotechnological production processes. However, due to the limited understanding of …

Drug discovery deals with the search for initial hits and their optimization toward a targeted
clinical profile. Throughout the discovery pipeline, the candidate profile will evolve, but the …

The recognition of the importance of drug-like properties beyond potency to reduce clinical
attrition of biologics has driven significant progress in the development of in vitro and in …