[PDF][PDF] Intrinsic and extrinsic molecular determinants or modulators for epigenetic remodeling and reprogramming of somatic cell-derived genome in mammalian …

M Samiec, M Skrzyszowska - Polish Journal of Veterinary Sciences, 2018 - journals.pan.pl
The efficiency of somatic cell cloning in mammals remains disappointingly low. Incomplete
and aberrant reprogramming of epigenetic memory of somatic cell nuclei in preimplantation …

Trichostatin A‐Mediated Epigenetic Transformation of Adult Bone Marrow‐Derived Mesenchymal Stem Cells Biases the In Vitro Developmental Capability, Quality …

M Samiec, J Opiela, D Lipiński… - BioMed research …, 2015 - Wiley Online Library
The current research was conducted to explore the in vitro developmental outcome and
cytological/molecular quality of porcine nuclear‐transferred (NT) embryos reconstituted with …

[PDF][PDF] High developmental capability of porcine cloned embryos following trichostatin A-dependent epigenomic transformation during in vitro maturation of oocytes pre-exposed …

M Samiec, M Skrzyszowska - 2012 - igbzpan.pl
The study was carried out in order to evolve, adopt and optimize the new system for
preparation of nuclear recipient cells at different stages preceding the somatic cell nuclear …

In vitro development and cytological quality of inter-species (porcine→ bovine) cloned embryos are affected by trichostatin A-dependent epigenomic modulation of …

J Opiela, M Samiec, J Romanek - Theriogenology, 2017 - Elsevier
Artificial epigenomic modulation of in vitro cultured mesenchymal stem cells (MSCs) by
applying a non-selective HDAC inhibitor, termed TSA, can facilitate more epigenetic …

Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A …

SF Ning, QY Li, MM Liang, XG Yang, HY Xu, YQ Lu… - Zygote, 2013 - cambridge.org
Reprogramming of DNA methylation in somatic cell nuclear transfer (SCNT) embryos is
incomplete, and aberrant DNA methylation patterns are related to the inefficiency of SCNT …

Effects of Histone Acetylation Status on the Early Development of In Vitro Porcine Transgenic Cloned Embryos

B Luo, S Ju, CW Muneri, R Rui - Cellular Reprogramming (Formerly" …, 2015 - liebertpub.com
The purpose of this study was to investigate the effects of the histone deacetylase (HDAC)
inhibitor trichostatin A (TSA) on transgene expression and development of porcine …

Differential effects of follistatin on porcine oocyte competence and cumulus cell gene expression in vitro

Z Guo, MS Islam, D Liu, G Liu, L Lv… - … in Domestic Animals, 2018 - Wiley Online Library
Contents Several oocyte‐derived genes/proteins are essential to early embryonic
development. The expression and stability of these proteins are influenced by the …

[HTML][HTML] Cardiomyocyte marker expression in mouse embryonic fibroblasts by cell-free cardiomyocyte extract and epigenetic manipulation

T Talaei-Khozani, F Heidari, T Esmaeilpour… - Iranian Journal of …, 2014 - ncbi.nlm.nih.gov
Background: The regenerative capacity of the mammalian heart is quite limited. Recent
reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. We …

Improved preimplantation development of cloned porcine embryos through supplementation of histone deacetylase inhibitor MS-275

X Fang, AY Qamar, ST Shin, J Cho - Journal of veterinary clinics, 2019 - koreascience.kr
The objective of this study was to analyse the effects of MS-275 (Class I and II histone
deacetylase inhibitor) supplementation on the development of porcine in-vitro somatic …

A possible strategy to produce pigs resistant to porcine reproductive and respiratory syndrome virus

B Luo, S Ju, B Wang, R Rui - Antiviral research, 2013 - Elsevier
The purpose of this study was to enhance the production of transgenic cloned embryos with
porcine reproductive and respiratory syndrome virus (PRRSV) shRNA expression cassettes …