Aspirin and P2Y12 Inhibitors in platelet-mediated activation of neutrophils and monocytes
WC Schrottmaier, JB Kral, S Badrnya… - Thrombosis and …, 2015 - thieme-connect.com
Platelets are key players in haemostasis and represent a pivotal link between inflammation,
immunity and atherogenesis. Depending on the (patho) physiological environment platelets …
immunity and atherogenesis. Depending on the (patho) physiological environment platelets …
The function and regulation of platelet P2Y12 receptor
X Li, G Zhang, X Cao - Cardiovascular drugs and therapy, 2023 - Springer
In addition to the key role in hemostasis and thrombosis, platelets have also been wildly
acknowledged as immune regulatory cells and involving in the pathogenesis of …
acknowledged as immune regulatory cells and involving in the pathogenesis of …
Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells
Hepatic fibrosis is the primary determinant of mortality in patients with metabolic dysfunction–
associated steatohepatitis (MASH). Transforming growth factor–β (TGFβ), a master …
associated steatohepatitis (MASH). Transforming growth factor–β (TGFβ), a master …
The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges
P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …
Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage
MC Rico, O Perez-Leal, MF Barbe, M Amin, DJ Colussi… - Biomolecules, 2023 - mdpi.com
Extracellular histones, part of the protein group known as damage-associated molecular
patterns (DAMPs), are released from damaged or dying cells and can instigate cellular …
patterns (DAMPs), are released from damaged or dying cells and can instigate cellular …
Efficacy and safety of prasugrel in acute coronary syndrome patients
RM Nanau, F Delzor, MG Neuman - Clinical biochemistry, 2014 - Elsevier
Ischemic heart disease is the primary cause of death worldwide. The pathophysiological
process of cardiovascular diseases is linked to atheromatous plaque formation, while …
process of cardiovascular diseases is linked to atheromatous plaque formation, while …
Extracellular Histone 3.3 and Its Hyper-acetylated Isoform In-duce an Inflammatory Response and Damage Lung Tissue
MC Rico, O Perez-Leal, MF Barbe, M Amin, DJ Colussi… - 2023 - preprints.org
Excessive extracellular histones can damage cells despite their importance in DNA structure
and gene regulation. We previously showed the harmful effect of histone 3.3 (H3. 3) and its …
and gene regulation. We previously showed the harmful effect of histone 3.3 (H3. 3) and its …
A joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management …
GF Calogiuri, S Al-Sowaidi, E Nettis, G Cortellini… - International Journal of …, 2016 - Elsevier
The role and importance of thienopyridines such as ticlopidine, clopidogrel, and prasugrel is
well-established for several indications, ranging from prevention of acute coronary …
well-established for several indications, ranging from prevention of acute coronary …