Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral
blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We …

Alzheimer's disease is the most common form of progressive dementia, typified initially by
short term memory deficits which develop into a dramatic global cognitive decline. The …

Abstract High-fat diet (HFD)-induced obesity is a risk factor for cognitive impairment in
Alzheimer's disease (AD). It has been reported that two typical neuropathological markers of …

We perform a large-scale meta-analysis of 51 peer-reviewed 3xTg-AD mouse publications
to compare Alzheimer's disease (AD) quantitative clinical outcome measures, including …

Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …

Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging
exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood–brain …

Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

Cognitive decline, obesity and gut dysfunction or microbial dysbiosis occur in association.
Our aim was to identify gut microbiota-metabolomics signatures preceding dementia in …

In Alzheimer's disease (AD), both cholesterol and glucose dysmetabolism precede the onset
of memory deficit and contribute to the disease's progression. It is indeed now believed that …

The incidence of neurological disorders such as multiple sclerosis (MS), Alzheimer's
disease (AD) and Parkinson's disease (PD) is increasing throughout the world, but their …