Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Design and Synthesis of Novel Ultralong-Acting Peptides as EDP-EBP Interaction Inhibitors for Pulmonary Fibrosis Treatment
Y Wang, F Xue, W Cheng, Q Zhao, N Song… - Journal of Medicinal …, 2024 - ACS Publications
The increased remodeling of the extracellular matrix (ECM) in pulmonary fibrosis (PF)
generates bioactive ECM fragments called matricryptins, which include elastin-derived …
generates bioactive ECM fragments called matricryptins, which include elastin-derived …
[HTML][HTML] circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
W Wu, Z Wang, H Zhang, X Zhang, H Tian - Cell Biology and Toxicology, 2024 - Springer
Air pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular
RNAs (circRNAs) have been found to play a significant role in the advancement of IPF, but …
RNAs (circRNAs) have been found to play a significant role in the advancement of IPF, but …
Insights into the selective mechanism of PDE2/9a inhibitors from silico aspects
P Song, S Wang, R Han, H Wang, B Hu… - Journal of …, 2024 - Taylor & Francis
The selective design of competitive enzyme inhibitors is an extremely difficult task but
necessary work for certain types of systems, such as the phosphodiesterase (PDE) system …
necessary work for certain types of systems, such as the phosphodiesterase (PDE) system …
Fibrotic lung disease: early signs, treatment and outcomes
I Belo - 2024 - openarchive.ki.se
Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in
recent decades. Thanks to enhanced understanding on pathophysiological mechanisms …
recent decades. Thanks to enhanced understanding on pathophysiological mechanisms …
Investigating the role of phosphodiesterases in myofibroblast transformation in Peyronie's disease
S Harding - 2024 - aru.figshare.com
Introduction: Peyronie's disease (PD) is characterised by a fibrous plaque that forms in the
penile tunica albuginea (TA), leading to pain, penile deformity, and erectile dysfunction …
penile tunica albuginea (TA), leading to pain, penile deformity, and erectile dysfunction …