Objective The aim of this systematic review was to analyze the evidence about the efficacy of
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …

Infection with the parasitic helminth Schistosoma mansoni causes significant liver fibrosis
and extracellular matrix (ECM) remodeling. Matrix metalloproteinases (MMP) are important …

Osteoarthritis (OA), the most common arthritis worldwide, is a degenerative joint disease
characterized by progressive cartilage breakdown, subchondral remodeling, and synovial …

Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their
inhibitors control matrix turnover and function. Recent advances in our understanding of …

Purpose Bone diseases account for an enormous cost burden on health systems. Bone
disorders are considered as age-dependent diseases. The aging of world population has …

Osteoarthritis (OA) is a major disability of elderly people. Sesamin is the main compound in
Sesamun indicum Linn., and it has an anti-inflammatory effect by specifically inhibiting Δ5 …

Background Low-intensity pulsed ultrasound (LIPUS) is a mechanical stimulus that plays a
key role in regulating the differentiation of bone marrow mesenchymal stem cells (BMSCs) …

Cartilage matrix homeostasis involves a dynamic balance between numerous signals that
modulate chondrocyte functions. This study aimed at elucidating the role of the extracellular …

Abstract Ethnopharmacological relevance In traditional Chinese medicine, Gentiana
macrophylla Pall have been prescribed for the treatment of pain and inflammatory …

Background and purpose Little is known about biochemical mediators that correlate with the
initiation and progression of knee osteoarthritis (OA). We therefore valuated the roles of …