Peroxisomes are highly plastic organelles that are involved in several metabolic processes,
including fatty acid oxidation, ether lipid synthesis and redox homeostasis. Their abundance …

Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Maternal immune activation is associated with adverse offspring neurodevelopmental
outcomes, many mediated by in utero microglial programming. As microglia remain …

The lysosomal degradation of macromolecules produces diverse small metabolites exported
by specific transporters for reuse in biosynthetic pathways. Here we deorphanized the major …

The disruption of astrocytic catabolic processes contributes to the impairment of amyloid‐β
(Aβ) clearance, neuroinflammatory signaling, and the loss of synaptic contacts in late‐onset …

The race to uncover fission factors for lysosomal organelles heats up Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …

Despite intensive glucose control or blood pressure control, the remission of proteinuria in
patients with diabetic nephropathy remains extremely low. Tacrolimus has been successful …

Background Age-related macular degeneration (AMD) is the leading cause of blindness in
elderly people in the developed world, and the number of people affected is expected to …

Elevated exposures to fluoride have been linked to neurological diseases. Identifying
mechanisms of fluoride neurotoxicity and finding ways for prevention and treatment of …

The escalating prevalence of Parkinson's disease (PD) underscores the need for innovative
therapeutic interventions since current palliative measures, including the standard l-Dopa …