The 5-HT1B receptor - a potential target for antidepressant treatment

M Tiger, K Varnäs, Y Okubo, J Lundberg - Psychopharmacology, 2018 - Springer
Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin
hypothesis may be the model of MDD pathophysiology with the most support. The majority of …

Latest updates on the serotonergic system in depression and anxiety

J Lin, W Liu, J Guan, J Cui, R Shi, L Wang… - Frontiers in Synaptic …, 2023 - frontiersin.org
Psychiatric disorders are among the leading causes of global health burden, with
depression and anxiety being the most disabling subtypes. The two common disorders …

The value of extended amygdala structures in emotive effects of narcogenic with diverse chemical structure

RO Roik, AA Lebedev, PD Shabanov - Research Results in …, 2019 - cyberleninka.ru
Introduction: Studies on the mechanisms of the reinforcing action of opioid and non-opioid
narcotics confirmed the existence in the brain of a specialized system named the extended …

Exercise Modifies the Brain Metabolic Response to Chronic Cocaine Exposure Inhibiting the Stria Terminalis

C Hanna, R Yao, M Sajjad, M Gold, K Blum, PK Thanos - Brain Sciences, 2023 - mdpi.com
It is well known that exercise promotes health and wellness, both mentally and
physiologically. It has been shown to play a protective role in many diseases, including …

Studying the involvement of ghrelin in the mechanism of gambling addiction in rats after exposure to psychogenic stressors in early ontogenesis

AA Lebedev, SS Purveev, EA Sexte… - Journal of Evolutionary …, 2023 - Springer
We investigated the role of ghrelin and its receptors in the manifestation of gambling
addiction elements in rats exposed to early psychogenic stress. Rearing in conditions of …

Особенности вовлечения дофаминергической и серотонинергической систем мозга в положительные и отрицательные эмоциональные состояния у крыс

ЕР Бычков, АА Лебедев, НС Ефимов… - Обзоры по …, 2020 - elibrary.ru
Целью настоящей работы было изучение влияния стимуляции положительных и
отрицательных эмоциогенных зон латерального гипоталамуса на обмен моноаминов в …

Обмен моноаминов в прилежащем ядре и стриатуме при активации положительных и отрицательных эмоциогенных зон латерального гипоталамуса у крыс

ЕР Бычков, ИВ Карпова, АС Крюков, НС Ефимов… - Наркология, 2020 - elibrary.ru
Моноаминергические системы мозга участвуют в формировании положительных и
отрицательных эмоций. Норадреналин, дофамин и серотонин широко представлены в …

[PDF][PDF] Intranasal administration of ghrelin receptor antagonist [D-Lys-3]-GHRP-6 reduces the manifestations of impulsivity and compulsivity induced by maternal …

SS Pyurveev, AA Lebedev, ER Bychkov… - Research Results in …, 2024 - researchgate.net
Introduction: The aim of our study was to investigate the effects of ghrelin receptor antagonist
[D-Lys-3]-GHRP-6 on impulsivity and compulsivity in a model of gambling addiction in adult …

Stimulation of 5-HT receptors in anterodorsal BNST guides fear to predictable and unpredictable threat

M Hessel, HC Pape, T Seidenbecher - European …, 2020 - Elsevier
Through pharmacological manipulation of the serotonergic (5-Hydroxytryptamin, 5-HT)
system, combined with behavioral analysis, we tested the hypothesis that fear responses to …

Activation of 5-HT1B receptors in the Lateral Habenula attenuates the anxiogenic effects of cocaine

AK Klein, EM Purvis, K Ayala, L Collins, JT Krug… - Behavioural brain …, 2019 - Elsevier
Recent work has implicated the Lateral Habenula (LHb) in the production of anxiogenic and
aversive states. It is innervated by all the major monoamine neurotransmitter systems and …