Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

Multiple sclerosis (MS) exhibits many of the hallmarks of an inflammatory autoimmune
disorder including breakdown of the blood‐brain barrier (BBB), the recruitment of …

Objective CD4 T‐cell–dependent macrophage activation directed against a myelin or
oligodendrocyte antigen is generally thought to be the mechanism causing myelin …

Multiple sclerosis (MS) is an autoimmune demyelinating disease and a common cause of
neurological disability in young adults. The modest heritability of MS reflects complex …

Multiple sclerosis (MS) is a heterogeneous disease that develops as an interplay between
the immune system and environmental stimuli in genetically susceptible individuals. There is …

There is little agreement among neuropathologists regarding the timing and nature of
oligodendrocyte loss in multiple sclerosis (MS). This review describes changes that …

Highlights•Additional observations of HHV6-specific B and T cell reactivity in MS
CSF.•Evidence of correlations between HHV6 status, polymorphisms and response to …

Highlights•Persistent infections as reservoirs of infection and RNA virus epidemiology.•
Disease and immune consequences of persistent RNA virus infections.•The role of host …

Epstein-Barr virus (EBV) has been associated with multiple sclerosis (MS), however, most
studies examining the relationship between the virus and the disease have been based on …

Multiple sclerosis (MS) is a common and severe CNS disorder that is characterized by
myelin loss, chronic inflammation, axonal and oligodendrocyte pathology, and progressive …