Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine
C Hartmanshenn, M Scherholz… - … of pharmacokinetics and …, 2016 - Springer
Personalized medicine strives to deliver the 'right drug at the right dose'by considering inter-
person variability, one of the causes for therapeutic failure in specialized populations of …
person variability, one of the causes for therapeutic failure in specialized populations of …
Integration of a physiologically based pharmacokinetic and pharmacodynamic model for tegoprazan and its metabolite: Application for predicting food effect and …
A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for
tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under …
tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under …
[HTML][HTML] Feature extraction and reduced-order modelling of nitrogen plasma models using principal component analysis
Principal component analysis has been presented in recent research as an accurate and
efficient method to reduce the complex chemistry and kinetics of large reacting mechanisms …
efficient method to reduce the complex chemistry and kinetics of large reacting mechanisms …
PBPK modeling and simulation and therapeutic drug monitoring: Possible ways for antibiotic dose adjustment
Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the
research and development (R&D) of new drugs, post-market monitoring, and continued …
research and development (R&D) of new drugs, post-market monitoring, and continued …
On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology
RT Rao, ML Scherholz, C Hartmanshenn… - Computers & chemical …, 2017 - Elsevier
The use of models in biology has become particularly relevant as it enables investigators to
develop a mechanistic framework for understanding the operating principles of living …
develop a mechanistic framework for understanding the operating principles of living …
The development of a population physiologically based pharmacokinetic model for mycophenolic mofetil and mycophenolic acid in humans using data from plasma …
MM Alsmadi, MQ Alfarah, J Albderat… - … & Drug Disposition, 2019 - Wiley Online Library
Background Mycophenolic acid (MPA) is used widely to prevent graft rejection in kidney‐
transplant patients. Therapeutic drug monitoring (TDM) in plasma requires an invasive …
transplant patients. Therapeutic drug monitoring (TDM) in plasma requires an invasive …
Saliva versus plasma therapeutic drug monitoring of gentamicin in Jordanian preterm infants. Development of a physiologically-based pharmacokinetic (PBPK) model …
Gentamicin has proven to be a very successful treatment for bacterial infection, but it also
can cause adverse effects, especially ototoxicity, which is irreversible. Therapeutic drug …
can cause adverse effects, especially ototoxicity, which is irreversible. Therapeutic drug …
A physiologically-based approach to model-predictive control of anesthesia and analgesia
The application of closed-loop control systems in biomedicine unlocks prospects for
optimized drug delivery based on the measurement of patients' physiological variables …
optimized drug delivery based on the measurement of patients' physiological variables …
A physiologically-based model to predict individual pharmacokinetics and pharmacodynamics of remifentanil
S Cascone, G Lamberti, O Piazza, RA Abbiati… - European Journal of …, 2018 - Elsevier
Remifentanil based anesthesia is nowadays spread worldwide. This drug is characterized
by a rapid onset of the analgesic effects, but also by a rapid onset of the side effects. For this …
by a rapid onset of the analgesic effects, but also by a rapid onset of the side effects. For this …
[PDF][PDF] 化学工业的转型升级和过程系统工程(PSE)
杨友麒 - 化工进展, 2018 - hgjz.cip.com.cn
针对我国化学工业的转型升级问题, 本文首先介绍了此次转型升级的时代背景,
即国际上第四次工业革命正在迅猛展开, 而国内正面临经济结构的第二次转型 …
即国际上第四次工业革命正在迅猛展开, 而国内正面临经济结构的第二次转型 …