[HTML][HTML] Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …
safe and effective treatments are available. However, new approaches to symptom …
[HTML][HTML] The CLDN5 gene at the blood-brain barrier in health and disease
Y Hashimoto, C Greene, A Munnich… - Fluids and Barriers of the …, 2023 - Springer
The CLDN5 gene encodes claudin-5 (CLDN-5) that is expressed in endothelial cells and
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
forms tight junctions which limit the passive diffusions of ions and solutes. The blood–brain …
Polygenic risk scores in clinical psychology: bridging genomic risk to individual differences
R Bogdan, DAA Baranger… - Annual review of clinical …, 2018 - annualreviews.org
Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …
[HTML][HTML] Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer's …
In addition to the devastating symptoms of dementia, Alzheimer's disease (AD) is
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide …
[HTML][HTML] Genetic data and cognitively defined late-onset Alzheimer's disease subgroups
Categorizing people with late-onset Alzheimer's disease into biologically coherent
subgroups is important for personalized medicine. We evaluated data from five studies (total …
subgroups is important for personalized medicine. We evaluated data from five studies (total …
Genome-wide association identifies the first risk loci for psychosis in Alzheimer disease
MAA DeMichele-Sweet, L Klei, B Creese… - Molecular …, 2021 - nature.com
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
in Alzheimer disease (AD with psychosis, AD+ P). AD+ P affects~ 50% of individuals with …
[HTML][HTML] Polygenic score models for Alzheimer's disease: from research to clinical applications
The high prevalence of Alzheimer's disease (AD) among the elderly population and its lack
of effective treatments make this disease a critical threat to human health. Recent …
of effective treatments make this disease a critical threat to human health. Recent …
[HTML][HTML] Clustering by phenotype and genome-wide association study in autism
A Narita, M Nagai, S Mizuno, S Ogishima… - Translational …, 2020 - nature.com
Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous
characteristics. A simulation study demonstrated that attempts to categorize patients with a …
characteristics. A simulation study demonstrated that attempts to categorize patients with a …
[HTML][HTML] scGRNom: a computational pipeline of integrative multi-omics analyses for predicting cell-type disease genes and regulatory networks
Understanding cell-type-specific gene regulatory mechanisms from genetic variants to
diseases remains challenging. To address this, we developed a computational pipeline …
diseases remains challenging. To address this, we developed a computational pipeline …
[HTML][HTML] Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
Psychosis (delusions or hallucinations) in Alzheimer's disease (AD+ P) occurs in up to 50%
of individuals and is associated with significantly worse clinical outcomes. Atypical …
of individuals and is associated with significantly worse clinical outcomes. Atypical …