The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

An imbalance in the lineages of immunosuppressive regulatory T cells (Treg cells) and the
inflammatory TH17 subset of helper T cells leads to the development of autoimmune and/or …

Aberrant lineage specification of skeletal stem cells (SSCs) contributes to reduced bone
mass and increased marrow adipose tissue (MAT) in osteoporosis and skeletal aging …

The Hippo signaling pathway is important for controlling organ size and tissue homeostasis.
Originally identified in Drosophila melanogaster, the core components of the Hippo pathway …

Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers
worldwide. Although the etiologies for liver oncogenesis are relatively well defined, the exact …

Reactive oxygen species (ROS) are constantly produced in cells, an excess of which causes
oxidative stress. ROS has been linked to regulation of the Hippo pathway; however, the …

Trimethyltin (TMT) is widely used as a major component of plastic stabilizers in agriculture
and industry, and can accumulate in large quantities in the liver. To investigate the …

The microRNA (miR)-200s and their negative regulator ZEB1 have been extensively studied
in the context of the epithelial–mesenchymal transition. Loss of miR-200s has been shown …

The Hippo pathway and its regulatory target, YAP, has recently emerged as an important
biochemical signaling pathway that tightly governs epithelial tissue growth. Initially defined …

The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …