TNF-related apoptosis-inducing ligand (TRAIL) for bone sarcoma treatment: pre-clinical and clinical data

Z Gamie, K Kapriniotis, D Papanikolaou, E Haagensen… - Cancer letters, 2017 - Elsevier
Bone sarcomas are rare, highly malignant mesenchymal tumours that affect teenagers and
young adults, as well as older patients. Despite intensive, multimodal therapy, patients with …

Intracellular localization of DR5 and related regulatory pathways as a mechanism of resistance to TRAIL in cancer

U Mert, AD Sanlioglu - Cellular and Molecular Life Sciences, 2017 - Springer
TNF-related apoptosis-inducing ligand (TRAIL) is a prominent cytokine capable of inducing
apoptosis. It can bind to five different cognate receptors, through which diverse intracellular …

TRAIL-mediated signaling in prostate, bladder and renal cancer

C Voelkel-Johnson - Nature Reviews Urology, 2011 - nature.com
Tumor necrosis factor related apoptosis inducing ligand (TRAIL) is a death receptor ligand
that has the ability to preferentially initiate apoptosis in malignant cells with minimal toxicity …

[HTML][HTML] Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields

D Martin-Sanchez, M Fontecha-Barriuso… - Cell Death & …, 2018 - nature.com
Urinary tract-associated diseases comprise a complex set of disorders with a variety of
etiologic agents and therapeutic approaches and a huge global burden of disease …

[HTML][HTML] Role of TNF-related apoptosis-inducing ligand (TRAIL) in the pathogenesis of varicocele-induced testicular dysfunction

O Celik, O Kutlu, M Tekcan, C Celik-Ozenci… - Asian Journal of …, 2013 - ncbi.nlm.nih.gov
The higher frequency of varicocele in men with infertility has drawn attention and resulted in
increased research at the molecular level towards treatments. The aim of this study was to …

The anti-obesity drug orlistat promotes sensitivity to TRAIL by two different pathways in hormone-refractory prostate cancer cells Corrigendum in/10.3892/ijo …

J Fujiwara, Y Sowa, M Horinaka… - International …, 2012 - spandidos-publications.com
The administration of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one
of the expected cancer therapeutics. However, improvements are required in therapies …

Androgen-responsive gene expression in prostate cancer progression

AH Tien, MD Sadar - Androgen-Responsive Genes in Prostate Cancer …, 2013 - Springer
Benign and cancerous prostate tissue is dependent upon androgens. Androgen ablation
causes prostate tissue to undergo apoptosis which thereby provides the rationale of …

肿瘤坏死因子相关的凋亡诱导配体在前列腺癌治疗中的研究进展

马继慈, 张青川 - 中华男科学杂志, 2015 - cqvip.com
肿瘤坏死因子相关的凋亡诱导配体(TRAIL) 是近年来研究发现的肿瘤坏死因子超家族新成员,
其广泛存在于人体组织中, 参与机体免疫调节, 免疫自稳和免疫监视. TRAIL 受体表达于多种细胞 …

Preclinical testing of a targeted TRAIL therapeutic for bone sarcoma

ZEK Gamie - 2020 - theses.ncl.ac.uk
Background: TNF-related apoptosis-inducing ligand (TRAIL) can induce cell death in cancer
cells after binding to its TRAIL receptors [TRAILR, Death Receptor 4 (DR4) and Death …

Estrogenic Regulation of the SCF/c-KIT System in Prostate Cells: a Relationship with Prostate Cancer?

MIN Figueira - 2014 - search.proquest.com
Prostate cancer (PCa) is the most common type of oncological disorder in men, for which an
increasing incidence has been reported. Development and progression of PCa have been …