Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

The peptidergic system is the most abundant network of ligand-receptor-mediated signaling
in humans. However, the physiological roles remain elusive for numerous peptides and …

In the mid-1970s, an intense race to identify endogenous substances that activated the
same receptors as opiates resulted in the identification of the first endogenous opioid …

Peptides play important roles in regulating biological processes and form the basis of a
multiplicity of therapeutic drugs. To date, only about 300 peptides in human have confirmed …

The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …

Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides
and peptide hormones that perform multiple functions, including regulation of body weight …

Background It was long assumed that proteins are at least 100 amino acids (AAs) long.
Moreover, the detection of short translation products (eg coded from small Open Reading …

Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5
subunits. While the impact of bortezomib on protein stability is known, the effect of this drug …

PEN is an abundant peptide in the brain that has been implicated in the regulation of
feeding. We identified a receptor for PEN in mouse hypothalamus and Neuro2A cells. PEN …