Aromatase inhibitors for the treatment of breast cancer: A journey from the scratch
P Ratre, K Mishra, A Dubey, A Vyas… - Anti-Cancer Agents …, 2020 - ingentaconnect.com
Background: Estrogens are essential for the growth of breast cancer in the case of
premenopausal as well as in postmenopausal women. However, most of the breast cancer …
premenopausal as well as in postmenopausal women. However, most of the breast cancer …
Machine learning-assisted prediction of the biological activity of aromatase inhibitors and data mining to explore similar compounds
Designing molecules for drugs has been a hot topic for many decades. However, it is hard
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …
Effective anti-aromatase therapy to battle against estrogen-mediated breast cancer: Comparative SAR/QSAR assessment on steroidal aromatase inhibitors
A large number of world women populations are suffering from breast cancer. It is increasing
day by day that is quite alarming. The major reason behind breast tumors is upregulation of …
day by day that is quite alarming. The major reason behind breast tumors is upregulation of …
Flavonoids as promising anticancer agents: an in silico investigation of ADMET, binding affinity by molecular docking and molecular dynamics simulations
Cancer is one of the most concerning diseases to humankind. Various treatment strategies
are being employed for its treatment, out of which use of natural products is an essential …
are being employed for its treatment, out of which use of natural products is an essential …
Innovative screening for functional improved aromatic amine derivatives: Toxicokinetics, free radical oxidation pathway and carcinogenic adverse outcome pathway
Y Liu, X Li, Q Pu, R Fu, Z Wang, Y Li, X Li - Journal of Hazardous Materials, 2023 - Elsevier
Aromatic amines, one of the most widely used low-cost antioxidants in rubbers, have been
regarded as pollutants with human health concerns. To overcome this problem, this study …
regarded as pollutants with human health concerns. To overcome this problem, this study …
Molecular dynamics and 3D-QSAR studies on indazole derivatives as HIF-1α inhibitors
Hypoxia-inducible factor (HIF) is a transcriptional factor which plays a crucial role in tumour
metastasis thereby responsible for development of various forms of cancers. Indazole …
metastasis thereby responsible for development of various forms of cancers. Indazole …
Pharmacophore derived 3D-QSAR, molecular docking, and simulation studies of quinoxaline derivatives as ALR2 inhibitors
Abstract Aldose Reductase 2 (ALR2), a key enzyme of the polyol pathway, plays a crucial
role in the pathogenesis of diabetic complications. Quinoxaline scaffold-based compounds …
role in the pathogenesis of diabetic complications. Quinoxaline scaffold-based compounds …
De novo designing, assessment of target affinity and binding interactions against aromatase: discovery of novel leads as anti-breast cancer agents
SK Verma, P Ratre, AK Jain, C Liang, GD Gupta… - Structural Chemistry, 2021 - Springer
Aromatase inhibitors (AIs) have been emerged as promising anti-cancer agents for the
treatment of hormone dependent breast cancer (HDBC) in women because of their excellent …
treatment of hormone dependent breast cancer (HDBC) in women because of their excellent …
Gaussian field-based comparative 3D QSAR modelling for the identification of favourable pharmacophoric features of chromene derivatives as selective inhibitors of …
SK Verma, N Kumar, S Thareja - Structural Chemistry, 2021 - Springer
Aldehyde reductase (ALR1) and aldose reductase (ALR2) are both oxo-reductase enzymes
of aldo-keto reductase (AKR) superfamily involved in several cellular processes. ALR1 plays …
of aldo-keto reductase (AKR) superfamily involved in several cellular processes. ALR1 plays …
Multifaceted 3D-QSAR analysis for the identification of pharmacophoric features of biphenyl analogues as aromatase inhibitors
L Banjare, Y Singh, SK Verma, AK Singh… - Journal of …, 2023 - Taylor & Francis
Aromatase, a cytochrome P450 enzyme, is responsible for the conversion of androgens to
estrogens, which fuel the multiplication of cancerous cells. Inhibition of estrogen …
estrogens, which fuel the multiplication of cancerous cells. Inhibition of estrogen …