Current challenges in the development of vaccines for pneumonic plague

ST Smiley - Expert review of vaccines, 2008 - Taylor & Francis
Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and
exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we …

Immune defense against pneumonic plague

ST Smiley - Immunological reviews, 2008 - Wiley Online Library
Yersinia pestis is one of the world's most virulent human pathogens. Inhalation of this Gram‐
negative bacterium causes pneumonic plague, a rapidly progressing and usually fatal …

Protein phosphatases of pathogenic bacteria: role in physiology and virulence

A Sajid, G Arora, A Singhal, VC Kalia… - Annual review of …, 2015 - annualreviews.org
The role of protein phosphatases in pathogenic bacteria has been studied extensively over
the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and …

The plague doctor of Venice

CJ Mussap - Internal medicine journal, 2019 - Wiley Online Library
There is a distinctive Venetian carnival mask with sinister overtones and historical
significance to physicians because it belongs to the 'Doctor of the Plague'. The costume …

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation

PA Price, J Jin, WE Goldman - Proceedings of the National …, 2012 - National Acad Sciences
Disease progression of primary pneumonic plague is biphasic, consisting of a
preinflammatory and a proinflammatory phase. During the long preinflammatory phase …

Plague prevention and therapy: perspectives on current and future strategies

R Rosario-Acevedo, SS Biryukov, JA Bozue, CK Cote - Biomedicines, 2021 - mdpi.com
Plague, caused by the bacterial pathogen Yersinia pestis, is a vector-borne disease that has
caused millions of human deaths over several centuries. Presently, human plague infections …

[HTML][HTML] Yersinia pestis, a problem of the past and a re-emerging threat

JL Ditchburn, R Hodgkins - Biosafety and Health, 2019 - Elsevier
Yersinia pestis is the bacteria that causes plague, one of the deadliest diseases in human
history. Three major plague pandemics (the Justinian Plague, the Black Death and the …

Live-attenuated Yersinia pestis vaccines

X Wang, X Zhang, D Zhou, R Yang - Expert review of vaccines, 2013 - Taylor & Francis
Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is
no ideal plague vaccine available for human use, but a number of licensed killed whole-cell …

The smpB-ssrA Mutant of Yersinia pestis Functions as a Live Attenuated Vaccine To Protect Mice against Pulmonary Plague Infection

NA Okan, P Mena, JL Benach, JB Bliska… - Infection and …, 2010 - Am Soc Microbiol
ABSTRACT The bacterial SmpB-SsrA system is a highly conserved translational quality
control mechanism that helps maintain the translational machinery at full capacity. Here we …

Gr1+ Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague

Z Ye, EJ Kerschen, DA Cohen, AM Kaplan… - Infection and …, 2009 - Am Soc Microbiol
YopM, a protein toxin of Yersinia pestis, is necessary for virulence in a mouse model of
systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion …