With increasing awareness of both short-and long-term problems associated with liberal
perioperative opioid administration, the need for routinely and clinically feasible alternatives …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

The scarcity and limited risk/benefit ratio of painkillers available on the market, in addition to
the opioid crisis, warrant reflection on new innovation strategies. The pharmacopoeia of …

Background Patients who suffer from anorexia nervosa (AN) are characterized by
exceedingly lower body weight, micro-and macro-nutrient deficiencies, and hyposalivation …

Our previous study reported the multifunctional agonist for opioid and neuropeptide FF
receptors DN-9, along with its cyclic peptide analogues c [D-Cys2, Cys5]-DN-9 and c [D …

While opioids constitute the major component of perioperative analgesic regimens for
surgery in general, a variety of evidence points to an association between perioperative …

Abstract Purpose of Review Dual enkephalinase inhibitors (DENKIs) are pain medications
that indirectly activate opioid receptors and can be used as an alternative to traditional …

Although traditional opioids such as morphine and oxycodone are commonly used in the
management of acute postoperative pain, novel opioids may play a role as alternatives that …

Objectives Opiorphin is an analgesic peptide released by salivary glands and capsaicin an
agonist of TRPV1 receptors eliciting burning sensations. The primary objective of this study …

Aim Dual enkephalinase inhibitors (DENKIs) are involved in the regulation of nociception via
opioid receptors. The novel compound STR‐324 belongs to the DENKI pharmacological …