Uncovering the genetic architecture of major depression
There have been several recent studies addressing the genetic architecture of depression.
This review serves to take stock of what is known now about the genetics of depression, how …
This review serves to take stock of what is known now about the genetics of depression, how …
Results of the European Group for the Study of Resistant Depression (GSRD)—basis for further research and clinical practice
Objectives: The overview outlines two decades of research from the European Group for the
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …
Study of Resistant Depression (GSRD) that fundamentally impacted evidence-based …
Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts
C Fabbri, SP Hagenaars, C John, AT Williams… - Molecular …, 2021 - nature.com
Abstract Treatment-resistant depression (TRD) is a major contributor to the disability caused
by major depressive disorder (MDD). Primary care electronic health records provide an …
by major depressive disorder (MDD). Primary care electronic health records provide an …
[HTML][HTML] Identifying the common genetic basis of antidepressant response
Background Antidepressants are a first-line treatment for depression. However, only a third
of individuals experience remission after the first treatment. Common genetic variation, in …
of individuals experience remission after the first treatment. Common genetic variation, in …
Predicting patients who will drop out of out-patient psychotherapy using machine learning algorithms
B Bennemann, B Schwartz, J Giesemann… - The British Journal of …, 2022 - cambridge.org
Background About 30% of patients drop out of cognitive–behavioural therapy (CBT), which
has implications for psychiatric and psychological treatment. Findings concerning drop out …
has implications for psychiatric and psychological treatment. Findings concerning drop out …
Genetic underpinnings of sociability in the general population
Levels of sociability are continuously distributed in the general population, and decreased
sociability represents an early manifestation of several brain disorders. Here, we …
sociability represents an early manifestation of several brain disorders. Here, we …
Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study
Risperidone is routinely used in the clinical management of schizophrenia, but the treatment
response is highly variable among different patients. The genetic underpinnings of the …
response is highly variable among different patients. The genetic underpinnings of the …
Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder
Up to 60% of patients with major depressive disorder (MDD) do not respond to the first
treatment with antidepressants. Response to antidepressants is a polygenic trait, although …
treatment with antidepressants. Response to antidepressants is a polygenic trait, although …
Exome-wide association study of treatment-resistant depression suggests novel treatment targets
SB Shah, TN Peddada, C Song, M Mensah, H Sung… - Scientific Reports, 2023 - nature.com
Abstract Treatment-resistant depression (TRD) is a severe form of major depressive disorder
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
[HTML][HTML] Predictors and risk factors of treatment-resistant depression: A systematic review
SJ O'Connor, N Hewitt, J Kuc… - The Journal of Clinical …, 2023 - psychiatrist.com
Objective: To systematically review the literature to identify and categorize the predictors and
risk factors for treatment-resistant depression (TRD). Data Sources: Online databases …
risk factors for treatment-resistant depression (TRD). Data Sources: Online databases …