A central role for thiols in plant tolerance to abiotic stress

L Zagorchev, CE Seal, I Kranner… - International journal of …, 2013 - mdpi.com
Abiotic stress poses major problems to agriculture and increasing efforts are being made to
understand plant stress response and tolerance mechanisms and to develop new tools that …

A review on metronidazole: an old warhorse in antimicrobial chemotherapy

D Leitsch - Parasitology, 2019 - cambridge.org
The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

A Debnath, D Parsonage, RM Andrade, C He… - Nature medicine, 2012 - nature.com
Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …

Drug resistance in Giardia duodenalis

BRE Ansell, MJ McConville, SY Ma'ayeh… - Biotechnology …, 2015 - Elsevier
Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a
major contributor to diarrheal and post-infectious chronic gastrointestinal disease world …

Low-molecular-mass antioxidants in parasites

RL Krauth-Siegel, AE Leroux - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

[HTML][HTML] Entamoeba thiol-based redox metabolism: A potential target for drug development

G Jeelani, T Nozaki - Molecular and biochemical parasitology, 2016 - Elsevier
Amebiasis is an intestinal infection widespread throughout the world caused by the human
pathogen Entamoeba histolytica. Metronidazole has been a drug of choice against …

Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics

R Kabra, N Chauhan, A Kumar, P Ingale… - Progress in biophysics …, 2019 - Elsevier
Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …

Sulfate Activation in Mitosomes Plays an Important Role in the Proliferation of Entamoeba histolytica

F Mi-ichi, T Makiuchi, A Furukawa, D Sato… - PLoS neglected …, 2011 - journals.plos.org
Mitochondrion-related organelles, mitosomes and hydrogenosomes, are found in a
phylogenetically broad range of organisms. Their components and functions are highly …

Redox pathways as drug targets in microaerophilic parasites

D Leitsch, CF Williams, I Hrdý - Trends in parasitology, 2018 - cell.com
The microaerophilic parasites Entamoeba histolytica, Trichomonas vaginalis, and Giardia
lamblia jointly cause hundreds of millions of infections in humans every year. Other …

Digestive exophagy of biofilms by intestinal amoeba and its impact on stress tolerance and cytotoxicity

E Zanditenas, M Trebicz-Geffen, D Kolli… - npj Biofilms and …, 2023 - nature.com
The human protozoan parasite Entamoeba histolytica is responsible for amebiasis, a
disease endemic to developing countries. E. histolytica trophozoites colonize the large …