Alternative splicing and cancer: a systematic review

Y Zhang, J Qian, C Gu, Y Yang - Signal transduction and targeted …, 2021 - nature.com
The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

Clinical study of ultrasonographic risk factors for central lymph node metastasis of papillary thyroid carcinoma

Y Guang, W He, W Zhang, H Zhang, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Background Thyroid cancer is the most common malignancy of the endocrine system
worldwide. Papillary thyroid cancer (PTC) is the most common pathologic type. The …

Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer

Z Mou, J Spencer, JS McGrath, LW Harries - Human Genomics, 2023 - Springer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …

Immunological characteristics of alternative splicing profiles related to prognosis in bladder cancer

F Ye, Y Liang, Z Cheng, Y Liu, J Hu, W Li… - Frontiers in …, 2022 - frontiersin.org
Several studies have found that pathological imbalance of alterative splicing (AS) events is
associated with cancer susceptibility. carcinogenicity. Nevertheless, the relationship …

Alternative splicing acts as an independent prognosticator in ovarian carcinoma

Y Ouyang, K Xia, X Yang, S Zhang, L Wang, S Ren… - Scientific reports, 2021 - nature.com
Alternative splicing (AS) events associated with oncogenic processes present anomalous
perturbations in many cancers, including ovarian carcinoma. There are no reliable features …

[HTML][HTML] Development of a prognostic index and screening of prognosis related genes based on an immunogenomic landscape analysis of bladder cancer

GY Qu, Z Liu, G Yang, Y Xu, M Xiang, C Tang - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Background: Bladder cancer (BLCA) is one of the most common urinary tract malignant
tumors. It is associated with poor outcomes, and its etiology and pathogenesis are not fully …

Identification of a prognostic alternative splicing signature in oral squamous cell carcinoma

S Zhang, X Wu, P Diao, C Wang… - Journal of cellular …, 2020 - Wiley Online Library
Alternative splicing (AS) is critically associated with tumorigenesis and patient's prognosis.
Here, we systematically analyzed survival‐associated AS signatures in oral squamous cell …

The Role of Alternative Splicing in Cancer: Regulatory Mechanism, Therapeutic Strategy, and Bioinformatics Application

YJ Pan, B Liu, DS Pei - DNA and Cell Biology, 2022 - liebertpub.com
Alternative splicing (AS) can generate distinct transcripts and subsequent isoforms that play
differential functions from the same pre-mRNA. Recently, increasing numbers of studies …

Role of alternative splicing signatures in the prognosis of glioblastoma

Z Xie, H Wu, Y Dang, G Chen - Cancer medicine, 2019 - Wiley Online Library
Background Increasing evidence has validated the crucial role of alternative splicing (AS) in
tumors. However, comprehensive investigations on the entirety of AS and their clinical value …

Alternative splicing events as indicators for the prognosis of uveal melanoma

Q Wan, X Sang, L Jin, Z Wang - Genes, 2020 - mdpi.com
Growing evidence has revealed that abnormal alternative splicing (AS) events are closely
related to carcinogenic processes. However, the comprehensive study on the prognostic …