Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Inherited or acquired alterations in the structure and function of connexin proteins have long
been associated with disease. In the present work, we review current knowledge on the role …

The inner ear is a very complex sensory organ whose development and function depend on
finely balanced interactions among diverse cell types. The many different kinds of inner ear …

Aberrant opening of nonjunctional connexin hemichannels at the plasma membrane is
associated with many diseases, including ischemia and muscular dystrophy. Proper control …

Connexin family proteins assemble into hexameric channels called hemichannels/
connexons, which function as transmembrane channels or dock together to form gap …

Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

Hemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called
connexins (Cxs) are major pathways for intercellular communication. While HCs connect the …

Gap junctions and hemichannels comprised of connexins influence epidermal proliferation
and differentiation. Significant advances in our understanding of the functional role of …

Abstract Microplastics (MPs) and cadmium (Cd) are important environmental pollutants, that
damage the liver. However, the effect and mechanism of combined Cd and MPs exposure …

Patients with Duchenne muscular dystrophy (DMD) commonly present with severe
ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also …