Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …

Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

New neurons arise from quiescent adult neural progenitors throughout life in specific
regions of the mammalian brain. Little is known about the embryonic origin and …

First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

Droplet microfluidic methods have massively increased the throughput of single-cell
sequencing campaigns. The benefit of scale-up is, however, accompanied by increased …

Recent advances in the treatment of various cancers have resulted in the adaptation of
several novel immunotherapeutic strategies. Notably, the recent intervention through …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common dementia among the elderly. The pathophysiology of AD is characterized by two …

Background Aberrant hippocampal neurogenesis is an important pathological feature of
sepsis-associated encephalopathy. In the current study, we examined the potential role of …

Cancer is one of the leading causes of morbidity and mortality worldwide. Significant
improvements in the modern era of anticancer therapeutic strategies have increased the …