Review of technological challenges in personalised medicine and early diagnosis of neurodegenerative disorders

C Domínguez-Fernández, J Egiguren-Ortiz… - International Journal of …, 2023 - mdpi.com
Neurodegenerative disorders are characterised by progressive neuron loss in specific brain
areas. The most common are Alzheimer's disease and Parkinson's disease; in both cases …

An overview: Radiotracers and nano-radiopharmaceuticals for diagnosis of Parkinson's disease

N Ozolmez, M Silindir-Gunay… - Applied Radiation and …, 2023 - Elsevier
Parkinson's disease (PD) is a widespread progressive neurodegenerative disease. Clinical
diagnosis approaches are insufficient to provide an early and accurate diagnosis before a …

Brain noradrenergic innervation supports the development of Parkinson's tremor: a study in a reserpinized rat model

NG Pozzi, F Bolzoni, GEM Biella, G Pezzoli, CW Ip… - Cells, 2023 - mdpi.com
The pathophysiology of tremor in Parkinson's disease (PD) is evolving towards a complex
alteration to monoaminergic innervation, and increasing evidence suggests a key role of the …

One-Pot Radiosynthesis of [18F]Anle138b—5-(3-Bromophenyl)-3-(6-[18F]fluorobenzo[d][1,3]dioxol-5-yl)-1H-pyrazole—A Potential PET Radiotracer Targeting α …

VV Orlovskaya, OS Fedorova, NB Viktorov, DD Vaulina… - Molecules, 2023 - mdpi.com
Availability of PET imaging radiotracers targeting α-synuclein aggregates is important for
early diagnosis of Parkinson's disease and related α-synucleinopathies, as well as for the …

Distinguishing features of depression in dementia from primary psychiatric disease

DW Fisher, JT Dunn, H Dong - Discover Mental Health, 2024 - Springer
Depression is a common and devastating neuropsychiatric symptom in the elderly and in
patients with dementia. In particular, nearly 80% of patients with Alzheimer's Disease …

Imaging Biomarkers in Prodromal and Earliest Phases of Parkinson's Disease

H Theis, N Pavese, I Rektorová… - Journal of Parkinson's …, 2024 - content.iospress.com
Assessing imaging biomarker in the prodromal and early phases of Parkinson's disease
(PD) is of great importance to ensure an early and safe diagnosis. In the last decades …

Decoding Prodromal Parkinson's Disease: Clinical Differences between Isolated Hyposmia and REM Sleep Behavior Disorder

LV Banerjee, J Pasquini, R Henderson, N Pavese… - medRxiv, 2024 - medrxiv.org
Background: The prodromal phase of Parkinson's disease (PD), much like the disease itself,
displays marked heterogeneity, with varied rates of progression and symptom severities. A …

Design and development of potential α-synuclein PET tracers: synthesis and evaluation of diarylpyrazole-and 2-styrylbenzothiazole-based libraries

A Di Nanni - 2024 - tobias-lib.ub.uni-tuebingen.de
Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies
(DLB) are collectively identified as synucleinopathies, a group of neurodegenerative …

Search for Molecular Biomarkers of Parkinson's Disease. New Tissues and Methods

R Peter - Acta Medica Martiniana, 2023 - sciendo.com
A bstract Parkinson's disease (PD) is a chronic neurodegenerative disorder that is clinically
manifested by motor and non-mo tor symptoms. At the early stage of the disease, it can be …

[PDF][PDF] Identifikační záznam

D ZOGALA - core.ac.uk
Aim: The aim of the study was to analyze the results of semiquantitative assessment of
dopamine transporters scintigraphy n (DAT-SPECT) in patients with Parkinson's disease …