Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …

It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …

Necroptosis is generally considered as an inflammatory cell death form. The core regulators
of necroptotic signaling are receptor‐interacting serine–threonine protein kinases 1 (RIPK1) …

The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely
implicated in human disease, including renal, pulmonary, gut and skin inflammatory …

Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease.
Among purinoceptors, only P2Y14R is positively correlated with inflammatory score in …

Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory
diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney …

Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1,
RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular …

Abstract Background & Aims Silibinin-phospholipid complex (SPC) has been utilized to treat
acute liver injury clinically. Nevertheless, the hepatoprotective mechanism of SPC remains …

Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro
studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key …

The objective of this research was to investigate the role of lncRNA MALAT1 and HSP90 in
the regulation of neuronal necroptosis in mice with cerebral ischemia-reperfusion (CIR). We …