[HTML][HTML] The anticancer properties of tanshinones and the pharmacological effects of their active ingredients

L Fu, B Han, Y Zhou, J Ren, W Cao, G Patel… - Frontiers in …, 2020 - frontiersin.org
Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …

[HTML][HTML] Comprehensive transcriptome profiling of Salvia miltiorrhiza for discovery of genes associated with the biosynthesis of tanshinones and phenolic acids

W Zhou, Q Huang, X Wu, Z Zhou, M Ding, M Shi… - Scientific Reports, 2017 - nature.com
Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia
miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of …

SmJAZ8 acts as a core repressor regulating JA-induced biosynthesis of salvianolic acids and tanshinones in Salvia miltiorrhiza hairy roots

T Pei, P Ma, K Ding, S Liu, Y Jia, M Ru… - Journal of …, 2018 - academic.oup.com
Jasmonates (JAs) are important plant hormones that regulate a variety of plant development
and defense processes, including biosynthesis of secondary metabolites. The JASMONATE …

CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis

M Shi, Z Du, Q Hua, G Kai - Industrial Crops and Products, 2021 - Elsevier
Phenolic acids comprise the major bioactive compounds in Salvia miltiorrhiza, which can be
increased by abscisic acid (ABA) elicitation. However, the underlying regulation mechanism …

Overexpression of SmbHLH10 enhances tanshinones biosynthesis in Salvia miltiorrhiza hairy roots

B Xing, D Yang, H Yu, B Zhang, K Yan, X Zhang, R Han… - Plant science, 2018 - Elsevier
The bHLH transcription factors have important role in regulation of plant growth,
development, and secondary metabolism. Tanshinones are the major pharmaceutical …

[HTML][HTML] Research and development of natural product tanshinone I: pharmacology, total synthesis, and structure modifications

X Huang, L Jin, H Deng, D Wu, Q Shen… - Frontiers in …, 2022 - frontiersin.org
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat
cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble …

Improved phenolic acid content and bioactivities of Salvia miltiorrhiza hairy roots by genetic manipulation of RAS and CYP98A14

R Fu, M Shi, C Deng, Y Zhang, X Zhang, Y Wang, G Kai - Food chemistry, 2020 - Elsevier
Phenolic acids from Salvia miltiorrhiza have been widely used in nutritious, health-
promoting products with an increasing demand. In the current study, two biosynthetic genes …

Over‐expression of DXS gene enhances terpenoidal secondary metabolite accumulation in rose‐scented geranium and Withania somnifera: active involvement of …

JS Jadaun, NS Sangwan, LK Narnoliya… - Physiologia …, 2017 - Wiley Online Library
Rose‐scented geranium (Pelargonium spp.) is one of the most important aromatic plants
and is well known for its diverse perfumery uses. Its economic importance is due to presence …

Overexpression of SmbHLH148 induced biosynthesis of tanshinones as well as phenolic acids in Salvia miltiorrhiza hairy roots

B Xing, L Liang, L Liu, Z Hou, D Yang, K Yan, X Zhang… - Plant cell reports, 2018 - Springer
Key message SmbHLH148 activated the whole biosynthetic pathways of phenolic acids and
tanshinones, thus upregulated the production of both the two groups of pharmaceutical …

Biosynthesis and Regulatory Mechanisms of Bioactive Compounds in Salvia miltiorrhiza, a Model System for Medicinal Plant Biology

S Lu - Critical Reviews in Plant Sciences, 2021 - Taylor & Francis
Salvia miltiorrhiza is one of the most well known species in the genus Salvia of the
Lamiaceae with great economic, academic and medicinal value. It was recorded as a …