[HTML][HTML] RNA N6-methyladenosine modification in cancers: current status and perspectives
Abstract N 6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
messenger RNAs (mRNAs), has been shown to play critical roles in various normal …
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
LE Dobrolecki, SD Airhart, DG Alferez… - Cancer and Metastasis …, 2016 - Springer
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly
supplanting long-established traditional cell lines as preferred models for conducting basic …
supplanting long-established traditional cell lines as preferred models for conducting basic …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
[HTML][HTML] Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising …
leukemogenesis. Using structure-based rational design, we have developed two promising …
[HTML][HTML] RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia
Summary N 6-methyladenosine (m 6 A), the most abundant internal modification in mRNA,
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
[HTML][HTML] R-2HG exhibits anti-tumor activity by targeting FTO/m6A/MYC/CEBPA signaling
Summary R-2-hydroxyglutarate (R-2HG), produced at high levels by mutant isocitrate
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
dehydrogenase 1/2 (IDH1/2) enzymes, was reported as an oncometabolite. We show here …
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …
[HTML][HTML] FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase
Summary N 6-Methyladenosine (m 6 A) represents the most prevalent internal modification
in mammalian mRNAs. Despite its functional importance in various fundamental …
in mammalian mRNAs. Despite its functional importance in various fundamental …
Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism
Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …
[HTML][HTML] Inhibition of endosteal vascular niche remodeling rescues hematopoietic stem cell loss in AML
D Duarte, ED Hawkins, O Akinduro, H Ang… - Cell stem cell, 2018 - cell.com
Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) …
remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) …