Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Maintenance of the blood system requires balanced cell fate decisions by hematopoietic
stem and progenitor cells (HSPCs). Because cell fate choices are executed at the individual …

Recent pre-clinical and clinical research has provided evidence that cancer progression is
driven not only by a tumour's underlying genetic alterations and paracrine interactions within …

It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …

Hematopoietic stem cell (HSC) research took hold in the 1950s with the demonstration that
intravenously injected bone marrow cells can rescue irradiated mice from lethality by …

Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …

New high-dimensional, single-cell technologies offer unprecedented resolution in the
analysis of heterogeneous tissues. However, because these technologies can measure …

Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT
inflammation was proposed as a central mechanism connecting obesity with its metabolic …

There is increasing evidence showing that inflammation is an important pathogenic mediator
of the development of obesity-induced insulin resistance. It is now generally accepted that …