[HTML][HTML] Generalized genetic liability to substance use disorders

AP Miller, R Bogdan, A Agrawal… - The Journal of clinical …, 2024 - Am Soc Clin Investig
Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and
compared with individual SUDs is characterized by greater severity, additional psychiatric …

Shared and unique 3D genomic features of substance use disorders across multiple cell types

KB Trang, A Chesi, S Toikumo, JA Pippin, MC Pahl… - medRxiv, 2024 - medrxiv.org
Recent genome-wide association studies (GWAS) have revealed shared genetic
components among alcohol, opioid, tobacco and cannabis use disorders. However, the …

[HTML][HTML] Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample

Y Khan, CN Davis, Z Jinwala, KL Feuer, S Toikumo… - medRxiv, 2024 - ncbi.nlm.nih.gov
The etiology of substance use disorders (SUDs) and psychiatric disorders reflects a
combination of both transdiagnostic (ie, common) and disorder-level (ie, independent) …

Genome-wide association studies of lifetime and frequency cannabis use in 131,895 individuals

HHA Thorpe, P Fontanillas, JJ Meredith, MV Jennings… - medRxiv, 2024 - medrxiv.org
Cannabis is one of the most widely used drugs globally. Decriminalization of cannabis is
further increasing cannabis consumption. We performed genome-wide association studies …