Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …

The unique morphological and excitable properties of nerve cells endow them with
specialized properties that permit the reception, transmission, and storage of information. It …

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …

Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of
patients with cancer,–, but dysfunction due to T cell exhaustion is an important barrier to …

INTRODUCTION The ability to regenerate tissues lost to damage or disease is widely but
nonuniformly distributed in vertebrates. Some animals such as teleost fishes can regenerate …

Although the proteins that read the gene regulatory code, transcription factors (TFs), have
been largely identified, it is not well known which sequences TFs can recognize. We have …

Glycogen synthase kinase‐3 (GSK‐3) is a protein‐serine kinase implicated in the hormonal
control of several regulatory proteins including glycogen synthase and the transcription …

While fruits and vegetables are recommended for prevention of cancer and other diseases,
their active ingredients (at the molecular level) and their mechanisms of action less well …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …