Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …

Peripheral nerve lesion triggers alterations in the spinal microenvironment that contribute to
the pathogenesis of neuropathic pain. While neurons and glia have been implicated in these …

Microglia are the resident macrophages in the central nervous system (CNS). Any insult to
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …

Evidence indicates that central glial activation depends on nerve inputs from the site of injury
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …

Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for
advanced colorectal cancer. The dose-limiting toxicity of this compound is the development …

Microglia play a crucial role in the maintenance of neuronal homeostasis in the central
nervous system, and microglia production of immune factors is believed to play an important …

The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …